在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MDFIC Antibody

MDFIC Antibody

  • 中文名稱：
    MDFIC兔多克隆抗體
  • 貨號：
    CSB-PA889174OA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA889174OA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA889174OA01HU diluted at 1:300 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of U251 cells with CSB-PA889174OA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MDFIC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MDFIC
  • 別名：
    MDFIC antibody; MyoD family inhibitor domain-containing protein antibody; I-mfa domain-containing protein antibody; hIC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence from Human MyoD family inhibitor domain-containing protein (35-53AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MDFIC Antibody (CSB-PA889174OA01HU)，的標記方式是Non-conjugated。對于MDFIC Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA889174OB01HU MDFIC Antibody, HRP conjugated ELISA
    FITC CSB-PA889174OC01HU MDFIC Antibody, FITC conjugated
    Biotin CSB-PA889174OD01HU MDFIC Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
  • 基因功能參考文獻：
    1. GR directly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC activity. These findings identify a new binding partner for cytoplasmic GR that modulates the receptor transcriptome and contributes to the tissue-specific actions of glucocorticoids. PMID: 28223352
    2. HIC specifically interacts with HTLV-1 Tax and negatively regulates Tax transactivational activity by altering its subcellular distribution and stability. PMID: 26469549
    3. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin beta and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. PMID: 21401918
    4. These data reveal for the first time that I-mfa domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3beta complex. PMID: 20417616
    5. This study describes that the immune expression of HIC is cell-specific, dynamic, and identifies the HIC gene as an IL-2 responsive gene. PMID: 19428567
    6. strict regulation of HIC expression at the levels of mRNA stability, translation efficiency and protein stability suggests that expression of the HIC protein and its involvement in the various pathways is required only under specific cellular conditions PMID: 19582149
    7. Two isoforms, resulting from the use of a non-AUG (GUG) and a downstream in-frame AUG translation initiation codon, have different subcellular localization. PMID: 10671520

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.; [Isoform 2]: Cytoplasm. Note=Weak expression in the nucleus.
  • 蛋白家族：
    MDFI family
  • 組織特異性：
    Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
  • 數據庫鏈接：

    HGNC: 28870

    OMIM: 614511

    KEGG: hsa:29969

    STRING: 9606.ENSP00000257724

    UniGene: Hs.741413



主站蜘蛛池模板： 国产亚洲精品97在线视频一 | 国产成人精品自在线拍| 丝袜美腿丝袜亚洲综合| 成人h动漫精品一区二区无码| av国産精品毛片一区二区视频| 在线看片免费人成视频福利 | 久久久久久久久久久免费精品| 97影院理论午夜伦不卡| 影音先锋人妻啪啪av资源网站| 国产手机在线无码播放视频| 亚洲精品夜夜夜| 午夜电影网va内射| 天天爽天天爽天天爽| 九九精品无码专区免费| 国产三级视频在线观看视| 女人被狂爆到高潮免费视频| 女人爽到高潮免费看视频| 精品无码成人片一区二区98| 日韩精品一卡2卡3卡4卡新区| 国产高清午夜人成在线观看| 亚洲成a人片在线不卡一二三区 | 少女韩国电视剧在线观看完整 | 国产无吗一区二区三区在线欢| 久久久无码精品国产一区| 亚洲αv无码一区二区三区四区 | 国产精品无码一区二区在线| 国产麻豆剧传媒精品国产av| 性色香蕉av久久久天天网| 日本污ww视频网站| 99久久国产成人免费网站| 国产午夜精品免费一区二区三区| 日韩人妻中文无码一区二区七区| 久久久久亚洲精品无码网址| 内射人妻无码色ab麻豆| 少妇人妻精品无码专区视频| 婷婷五月深爱综合开心网| 亚洲日韩在线中文字幕线路2区 | 成年无码av片| 国产又色又爽又刺激在线播放| 污污污污污污污网站污| 午夜国产成人片在线播放|