在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MDFIC Antibody, FITC conjugated

  • 中文名稱:
    MDFIC兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA889174OC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MDFIC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MDFIC
  • 別名:
    MDFIC antibody; MyoD family inhibitor domain-containing protein antibody; I-mfa domain-containing protein antibody; hIC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human MyoD family inhibitor domain-containing protein (35-53AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
  • 基因功能參考文獻:
    1. GR directly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC activity. These findings identify a new binding partner for cytoplasmic GR that modulates the receptor transcriptome and contributes to the tissue-specific actions of glucocorticoids. PMID: 28223352
    2. HIC specifically interacts with HTLV-1 Tax and negatively regulates Tax transactivational activity by altering its subcellular distribution and stability. PMID: 26469549
    3. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin beta and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. PMID: 21401918
    4. These data reveal for the first time that I-mfa domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3beta complex. PMID: 20417616
    5. This study describes that the immune expression of HIC is cell-specific, dynamic, and identifies the HIC gene as an IL-2 responsive gene. PMID: 19428567
    6. strict regulation of HIC expression at the levels of mRNA stability, translation efficiency and protein stability suggests that expression of the HIC protein and its involvement in the various pathways is required only under specific cellular conditions PMID: 19582149
    7. Two isoforms, resulting from the use of a non-AUG (GUG) and a downstream in-frame AUG translation initiation codon, have different subcellular localization. PMID: 10671520

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.; [Isoform 2]: Cytoplasm. Note=Weak expression in the nucleus.
  • 蛋白家族:
    MDFI family
  • 組織特異性:
    Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
  • 數據庫鏈接:

    HGNC: 28870

    OMIM: 614511

    KEGG: hsa:29969

    STRING: 9606.ENSP00000257724

    UniGene: Hs.741413



主站蜘蛛池模板: 久久久久久夜精品精品免费啦| 美丽的熟妇中文字幕| 四川丰满少妇被弄到高潮| 香蕉影院在线观看| 人人妻一区二区三区| 免费看无码自慰一区二区| 精品国产免费人成电影在线看 | 尤物av无码国产在线看| 最新精品露脸国产在线| 中文字幕 亚洲精品 第1页| 日本va欧美va欧美va精品| 成人h动漫精品一区二区| 九九久久精品免费观看| 18禁超污无遮挡无码网址| 久久av高潮av无码av| 色老头在线一区二区三区| 女人18毛片水真多| 久久亚洲人成综合网| 亚洲国产成人精品无码区花野真一 | 999国产精品999久久久久久| 亚洲国产精品成人精品无码区在线| 日本久久高清一区二区三区毛片| 亚洲欧美中文字幕高清在线| 国产乱人伦无无码视频试看| 亚洲国产日韩精品一区二区三区| 亚洲欧美日韩久久一区二区| 人妻熟女一区二区aⅴ水野朝阳 | 亚洲综合色自拍一区| 欧洲日韩亚洲无线在码| 四虎精品国产永久在线观看| 97se色综合一区二区二区| 熟睡人妻被讨厌的公侵犯| 亚洲欧美综合中文| 国产乱子伦一区二区三区四区五区| 成人乱码一区二区三区av| 国产美女极度色诱视频www| 动漫精品专区一区二区三区不卡| 日本亚州视频在线八a| 欧美丰满熟妇bbb久久久| 国产精品乱码一区二区三区| 亚洲国产日韩在线人成蜜芽|