在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MDFIC Antibody

  • 中文名稱:
    MDFIC兔多克隆抗體
  • 貨號:
    CSB-PA986738
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA986738(MDFIC Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA986738(MDFIC Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    MDFIC
  • 別名:
    MDFIC antibody; MyoD family inhibitor domain-containing protein antibody; I-mfa domain-containing protein antibody; hIC antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human MDFIC
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
  • 基因功能參考文獻:
    1. GR directly represses the MDFIC gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC activity. These findings identify a new binding partner for cytoplasmic GR that modulates the receptor transcriptome and contributes to the tissue-specific actions of glucocorticoids. PMID: 28223352
    2. HIC specifically interacts with HTLV-1 Tax and negatively regulates Tax transactivational activity by altering its subcellular distribution and stability. PMID: 26469549
    3. We demonstrate that HIC selectively interferes with Rev NLS interaction with importin beta and impedes its nuclear import and function, but does not affect Rev nuclear import mediated by transportin. PMID: 21401918
    4. These data reveal for the first time that I-mfa domain proteins interact with LANA and negatively regulate LANA-mediated activation of Wnt signaling-dependent transcription by inhibiting the formation of the LANA.GSK-3beta complex. PMID: 20417616
    5. This study describes that the immune expression of HIC is cell-specific, dynamic, and identifies the HIC gene as an IL-2 responsive gene. PMID: 19428567
    6. strict regulation of HIC expression at the levels of mRNA stability, translation efficiency and protein stability suggests that expression of the HIC protein and its involvement in the various pathways is required only under specific cellular conditions PMID: 19582149
    7. Two isoforms, resulting from the use of a non-AUG (GUG) and a downstream in-frame AUG translation initiation codon, have different subcellular localization. PMID: 10671520

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.; [Isoform 2]: Cytoplasm. Note=Weak expression in the nucleus.
  • 蛋白家族:
    MDFI family
  • 組織特異性:
    Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
  • 數據庫鏈接:

    HGNC: 28870

    OMIM: 614511

    KEGG: hsa:29969

    STRING: 9606.ENSP00000257724

    UniGene: Hs.741413



主站蜘蛛池模板: 亚洲精品国产精品无码国模| 久久精品中文字幕| 久久综合亚洲色hezyo国产 | 国产精品亚洲五月天高清| 日韩精品专区在线影院重磅 | 2020国产精品午夜福利在线观看| 5d肉蒲团之性战奶水| 波多野结衣av无码| 性夜影院午夜看片| 天天摸天天做天天添欧美| 最近中文av字幕在线中文| 日韩av无码中文字幕| 午夜在线a亚洲v天堂网2018| 亚洲天堂在线观看完整版| 国产在线视频www色| 午夜无码片在线观看影院| 国产有奶水哺乳期无码avav| 国产在线播放精品视频| 欧美综合在线激情专区| 天堂8在线新版官网| 日本少妇肉体裸交xxx| 久久人人97超碰a片精品| 国产色综合天天综合网| 男女啪祼交视频| 国产在线精品一区二区三区直播| 在线天堂最新版资源| 99热精品久久只有精品| 在线 | 麻豆国产传媒61国产免费| 亚洲精品国产自在现线看| 国产成人一区二区三区app| 成熟丰满熟妇av无码区| 青青国产揄拍视频| 成人免费乱码大片a毛片| 东京热无码av一区二区| 四虎永久在线精品免费网址| 爆乳高潮喷水无码正在播放| 亚洲男女一区二区三区| 99精品国产一区二区三区| 国产成人亚洲日韩欧美| 99re6这里有精品热视频| 亚洲妇熟xxxx妇色黄|