在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCM9 Antibody

MCM9 Antibody

  • 中文名稱：
    MCM9兔多克隆抗體
  • 貨號(hào)：
    CSB-PA882135LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, MCF7 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate, Mouse Brain tissue lysate, Mouse Brain tissue lysate
      All lanes: MCM9 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 127/85/72/48 kDa
      Observed band size: 127 kDa
    • Immunofluorescence staining of MCF7 cell with CSB-PA882135LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunofluorescence staining of MCF7 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The polyclonal antibody against MCM9 was produced in rabbits and exhibits specific binding to the human and mouse MCM9 protein. The immunogen used to generate this antibody is the recombinant human DNA helicase MCM9 protein comprising 1-391 amino acids. Following immunization, the antibody was collected from the rabbit serum and purified via protein G chromatography, resulting in a purity level of 95%+.

    This MCM9 antibody has been extensively tested in various applications such as ELISA, WB, and IHC, and it is capable of reacting with human and mouse samples. The MCM9 polyclonal antibody is a useful tool for investigating the expression, localization, and activity of MCM9 in various experimental contexts.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MCM9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCM9
  • 別名：
    MCM9 antibody; C6orf61 antibody; MCMDC1DNA helicase MCM9 antibody; hMCM9 antibody; EC 3.6.4.12 antibody; Mini-chromosome maintenance deficient domain-containing protein 1 antibody; Minichromosome maintenance 9 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DNA helicase MCM9 protein (1-391AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，MCM9 Antibody (CSB-PA882135LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于MCM9 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA882135LB01HU MCM9 Antibody, HRP conjugated ELISA
    FITC CSB-PA882135LC01HU MCM9 Antibody, FITC conjugated
    Biotin CSB-PA882135LD01HU MCM9 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.02% sodium azide; Constituents: PBS containing 50% glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
  • 基因功能參考文獻(xiàn)：
    1. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    2. Significant number of potentially damaging and novel variants in MCM9 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    3. Study identified fifteen variants that included six common SNPs and nine variants of unknown significance (VUS) in MCM9 gene. However VUS occur in MCM9 in a small proportion of Lynch-like syndrome (LLS) patients and MCM9 mutations are unlikely to explain most LLS cases. PMID: 27886675
    4. Data show that the two affected sisters were homozygous for the mutation of MCM9 gene, encoding the minichromosome maintenance complex component 9. PMID: 26771056
    5. MCM9 loading onto chromatin is MSH2-dependent, and in turn MCM9 stimulates the recruitment of MLH1 to chromatin, revealing a role for MCM9 and its helicase activity in DNA mismatch repair. PMID: 26300262
    6. Autosomal-recessive variants in MCM9 cause a genomic-instability syndrome associated with hypergonadotropic hypogonadism and short stature. PMID: 25480036
    7. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    8. A novel alternatively spliced variant of MCM9 is specifically induced after exposure to Mitomycin C. Expression is cell-cycle regulated and induced in S-phase. PMID: 23403237
    9. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells. PMID: 15850810
    10. We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 signature domain, is an incomplete form of the full length HsMCM9 described here. PMID: 16226853
    11. Cdt1, with its two opposing regulatory binding factors MCM9 and geminin, appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals. PMID: 18657502

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Ovarian dysgenesis 4 (ODG4)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    MCM family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21484

    OMIM: 610098

    KEGG: hsa:254394

    STRING: 9606.ENSP00000314505

    UniGene: Hs.279008



主站蜘蛛池模板： 国产成人av性色在线影院色戒 | 醉酒后少妇被疯狂内射视频| 国产九九99久久99大香伊| 国产精品国产对白熟妇| 在线精品国产大象香蕉网| 综合色一色综合久久网| 国产欧美成人一区二区a片| 国产精品爽爽久久久久久| 久久精品国产99国产精品导航| 久久男人av资源站| 97精品国产久热在线观看| 视频二区丝袜国产欧美日韩| 在线 | 一区二区三区四区| 精品夜夜爽欧美毛片视频| 秋霞国产成人精品午夜视频app| 亚洲综合色在线观看一区| 无码专区—va亚洲v专区| 香蕉av777xxx色综合一区| 亚洲熟妇久久精品| 国产无夜激无码av毛片| 夜夜添无码试看一区二区三区| 久久97久久97精品免视看| 国产伦孑沙发午休精品| 女的被弄到高潮娇喘喷水视频| 国产又黄又爽又色的免费| 久久久无码精品国产一区 | 天天爽夜夜爽人人爽曰| 97色伦图片97综合影院| 国产寡妇偷人在线观看| 美女扒开腿让男人桶爽揉| 国产成年无码久久久久毛片 | 亚洲日韩在线a视频在线观看| 97久久超碰中文字幕| 久久伊人蜜桃av一区二区| 久久久欧美国产精品人妻噜噜 | 成人三级无码视频在线观看| 国产成人精品日本亚洲第一区| 欧美又粗又长又爽做受| 久久国产精品免费一区| 欧美xxxx黑人又粗又长| 99精品国产免费观看视频|