在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MCM9 Antibody, HRP conjugated

  • 中文名稱:
    MCM9兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA882135LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MCM9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MCM9
  • 別名:
    MCM9 antibody; C6orf61 antibody; MCMDC1DNA helicase MCM9 antibody; hMCM9 antibody; EC 3.6.4.12 antibody; Mini-chromosome maintenance deficient domain-containing protein 1 antibody; Minichromosome maintenance 9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA helicase MCM9 protein (1-391AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis.
  • 基因功能參考文獻:
    1. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    2. Significant number of potentially damaging and novel variants in MCM9 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    3. Study identified fifteen variants that included six common SNPs and nine variants of unknown significance (VUS) in MCM9 gene. However VUS occur in MCM9 in a small proportion of Lynch-like syndrome (LLS) patients and MCM9 mutations are unlikely to explain most LLS cases. PMID: 27886675
    4. Data show that the two affected sisters were homozygous for the mutation of MCM9 gene, encoding the minichromosome maintenance complex component 9. PMID: 26771056
    5. MCM9 loading onto chromatin is MSH2-dependent, and in turn MCM9 stimulates the recruitment of MLH1 to chromatin, revealing a role for MCM9 and its helicase activity in DNA mismatch repair. PMID: 26300262
    6. Autosomal-recessive variants in MCM9 cause a genomic-instability syndrome associated with hypergonadotropic hypogonadism and short stature. PMID: 25480036
    7. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    8. A novel alternatively spliced variant of MCM9 is specifically induced after exposure to Mitomycin C. Expression is cell-cycle regulated and induced in S-phase. PMID: 23403237
    9. Identified a novel MCM family gene, MCM9, by using bioinformatics; mouse MCM9 mRNA was upregulated by transcription factor E2E1 and serum stimulation in NIH3T3 cells. PMID: 15850810
    10. We also show that the very recently reported human MCM9 protein (HsMCM9), which resembles a truncated MCM-like protein missing a part of the MCM2-7 signature domain, is an incomplete form of the full length HsMCM9 described here. PMID: 16226853
    11. Cdt1, with its two opposing regulatory binding factors MCM9 and geminin, appears to be a major platform on the pre-replication complexes to integrate cell-cycle signals. PMID: 18657502

    顯示更多

    收起更多

  • 相關疾病:
    Ovarian dysgenesis 4 (ODG4)
  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    MCM family
  • 數據庫鏈接:

    HGNC: 21484

    OMIM: 610098

    KEGG: hsa:254394

    STRING: 9606.ENSP00000314505

    UniGene: Hs.279008



主站蜘蛛池模板: 日本牲交大片无遮挡| 色哟哟最新在线观看入口| 日韩欧美亚洲中文乱码| 欧美人与动牲交zooz| 亚洲男人的天堂av手机在线观看| 日本夜爽爽一区二区三区| 少妇性l交大片| 久久精品人妻无码一区二区三区v 国产薄丝脚交视频在线观看 | 亚洲综合色区另类小说| 久久996re热这里有精品| 亚洲综合色区中文字幕| 国产成a人亚洲精品无码久久网| 香蕉久久久久久久av网站| 国产精品 自在自线| 67194熟妇人妻欧美日韩| 韩国三级中文字幕hd| 国产精品久久国产三级国| 中国xxxx做受视频| 欧美做受视频播放| 欧美欧洲成本大片免费| 1000部拍拍拍18勿入免费视频下载| 噜噜噜亚洲色成人网站| 熟女人妻av粗壮巨龙| 韩国 欧美 日产 国产精品| 国产精品毛片在线完整版sab| 亚洲熟妇无码av| 国产激情无码一区二区三区| 中文字幕无码av正片| 中老年熟妇激情啪啪大屁股| 免费无码又爽又黄又刺激网站| 中文天堂国产最新| 蜜臀亚洲精品国产aⅴ综合第一| 无码少妇一区二区三区免费 | 日本高清一区二区三| 国产乱人伦偷精品视频| 老司机无码精品a| 国色天香精品一卡2卡3卡4| 无码播放一区二区三区| 亚洲午夜久久久久久久久电影网| 影音先锋人妻av中文字幕久久 | 无码专区亚洲制服丝袜|