在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCC Antibody

MCC Antibody

  • 中文名稱：
    MCC兔多克隆抗體
  • 貨號：
    CSB-PA826358
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA826358(MCC Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA826358(MCC Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MCC
  • 別名：
    Colorectal mutant cancer protein antibody; CRCM_HUMAN antibody; DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC 1 antibody; MCC antibody; MCC1 antibody; Mutated in colorectal cancers antibody; Protein MCC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MCC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.
  • 基因功能參考文獻：
    1. Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin mediated cell-cell adhesion in colorectal cancer cells. PMID: 29035389
    2. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    3. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression. PMID: 27226254
    4. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells PMID: 25200342
    5. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 PMID: 24824780
    6. targeted by miR-494, which is overexpressed in hepatocellular carcinoma PMID: 23913442
    7. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex. PMID: 22480440
    8. we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci. PMID: 22542170
    9. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer. PMID: 22213290
    10. observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population PMID: 21279955
    11. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction. PMID: 18591935
    12. Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2. PMID: 19555689

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
  • 蛋白家族：
    MCC family
  • 組織特異性：
    Expressed in a variety of tissues.
  • 數據庫鏈接：

    HGNC: 6935

    OMIM: 159350

    KEGG: hsa:4163

    STRING: 9606.ENSP00000386227

    UniGene: Hs.593171



主站蜘蛛池模板： 久久精品无码中文字幕| 欧美肥老太牲交大战| 国产毛片久久久久久国产毛片| 亚洲中文字幕无码一区二区三区 | 国产老熟女伦老熟妇露脸| 熟女少妇精品一区二区| 日韩卡1卡2 卡三卡免费| 夜夜躁狠狠躁日日躁2022| 天天摸夜夜添夜夜无码| 久久国产精品免费一区二区三区| 精品久久久久久久久午夜福利| 50岁熟妇的呻吟声对白| 欧美成人一区二区三区片免费 | 久久人人爽人人爽人人片av| 国产在线拍揄自揄视频导航| av无码欧洲亚洲电影网| 国产suv精品一区二区四| 男女同房做爰爽免费| 无码人妻天天拍夜夜爽 | 久久aaaa片一区二区| 黑人巨茎大战欧美白妇免费| 亚洲精品午夜无码电影网| 浴室人妻的情欲hd三级国产| 免费无码国产v片在线观看| 国产日韩另类综合11页| 免费大香伊蕉在人线国产卡| 欧美牲交a欧美牲交| 少妇愉情理伦片丰满丰满午夜| 久久久久久成人综合网| 18无码粉嫩小泬无套在线观看| 国产精品人人爽人人做我的可爱| 国产超薄肉色丝袜视频| 精品久久久久中文字幕app| 欧美与黑人午夜性猛交久久久 | 国产亚洲精品久久久美女18黄| 最新国产精品久久精品| 国产精品久久久午夜夜伦鲁鲁| 无码人妻精品一区二| 日本护士xxxxhd少妇| 色噜噜av男人的天堂| 精品人妻伦九区久久aaa片69|