在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCC Antibody, Biotin conjugated

MCC Antibody, Biotin conjugated

  • 中文名稱：
    MCC兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA013571LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MCC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCC
  • 別名：
    Colorectal mutant cancer protein antibody; CRCM_HUMAN antibody; DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC 1 antibody; MCC antibody; MCC1 antibody; Mutated in colorectal cancers antibody; Protein MCC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Colorectal mutant cancer protein (479-611AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.
  • 基因功能參考文獻：
    1. Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin mediated cell-cell adhesion in colorectal cancer cells. PMID: 29035389
    2. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    3. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression. PMID: 27226254
    4. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells PMID: 25200342
    5. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 PMID: 24824780
    6. targeted by miR-494, which is overexpressed in hepatocellular carcinoma PMID: 23913442
    7. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex. PMID: 22480440
    8. we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci. PMID: 22542170
    9. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer. PMID: 22213290
    10. observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population PMID: 21279955
    11. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction. PMID: 18591935
    12. Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2. PMID: 19555689

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
  • 蛋白家族：
    MCC family
  • 組織特異性：
    Expressed in a variety of tissues.
  • 數據庫鏈接：

    HGNC: 6935

    OMIM: 159350

    KEGG: hsa:4163

    STRING: 9606.ENSP00000386227

    UniGene: Hs.593171



主站蜘蛛池模板： yyyy11111少妇影院| 丰满熟女人妻中文字幕免费| 草色噜噜噜av在线观看香蕉| 色欲一区二区三区精品a片| 亚洲毛片无码不卡av在线播放| 婷婷激情综合色五月久久竹菊影视 | 国产亚洲精品aaaa片小说| 熟妇熟女乱妇乱女网站| 中文字幕一区二区精品区| 国产亚洲综合区成人国产系列| 福利一区二区三区视频在线观看| 丰满少妇女裸体bbw| av无码国产精品麻豆| 一区二区三区四区在线不卡高清 | 欧美日韩一本的免费高清视频| 无码人妻av免费一区二区三区| 国产一区二区三区四区五区加勒比| 国产亚洲精品第一综合另类灬| 日韩人妻不卡一区二区三区| 亚洲综合久久一本久道| 国产精品无码免费播放| 日日av色欲香天天综合网| 免费人成又黄又爽的视频 | 免费中文熟妇在线影片| 亚洲精品一区二区三区在线观看| 护士张开腿被奷日出白浆| 久久中文骚妇内射| 久久这里只精品国产免费10| 亚洲欧洲日产国码韩国| 产后漂亮奶水人妻无码| 无码免费一区二区三区| 毛茸茸性xxxx毛茸茸毛茸茸| 精产国品一二三产区9977| 天天躁夜夜躁狠狠综合2020| 日韩少妇内射免费播放18禁裸乳 | 亚洲日产av中文字幕无码偷拍| 国产放荡对白视频在线观看| 国产suv精品一区二区| 最近中文2019字幕第二页| 国产精品无码a∨果冻传媒| 亚洲精品在看在线观看高清|