在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCC Antibody, HRP conjugated

MCC Antibody, HRP conjugated

  • 中文名稱：
    MCC兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA013571LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MCC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCC
  • 別名：
    Colorectal mutant cancer protein antibody; CRCM_HUMAN antibody; DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC 1 antibody; MCC antibody; MCC1 antibody; Mutated in colorectal cancers antibody; Protein MCC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Colorectal mutant cancer protein (479-611AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.
  • 基因功能參考文獻：
    1. Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin mediated cell-cell adhesion in colorectal cancer cells. PMID: 29035389
    2. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    3. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression. PMID: 27226254
    4. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells PMID: 25200342
    5. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 PMID: 24824780
    6. targeted by miR-494, which is overexpressed in hepatocellular carcinoma PMID: 23913442
    7. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex. PMID: 22480440
    8. we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci. PMID: 22542170
    9. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer. PMID: 22213290
    10. observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population PMID: 21279955
    11. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction. PMID: 18591935
    12. Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2. PMID: 19555689

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
  • 蛋白家族：
    MCC family
  • 組織特異性：
    Expressed in a variety of tissues.
  • 數據庫鏈接：

    HGNC: 6935

    OMIM: 159350

    KEGG: hsa:4163

    STRING: 9606.ENSP00000386227

    UniGene: Hs.593171



主站蜘蛛池模板： 四虎影视久久久免费观看| 天天躁日日躁狠狠躁视频2021| 激情综合色综合啪啪五月丁香| 国产成人无码国产亚洲| 亚洲国产精品无码7777一线| 国产麻豆精品福利在线观看| 国产精品久久久久久亚洲毛片| 色翁荡息又大又硬又粗又爽电影| 久久中文精品无码中文字幕| 中文午夜人妻无码看片| 国产美女在线精品免费观看网址| 老子午夜精品无码| 国精品午夜福利视频| 久久99精品国产99久久6男男 | 久久人妻av无码中文专区| 国产婷婷成人久久av免费高清| 久久久久青草线蕉亚洲麻豆| 日本一卡二卡3卡四卡网站精品 | 中文字幕亚洲综合久久蜜桃| 人妻色综合网站| 天堂aⅴ无码一区二区三区| 鲁一鲁av2019在线| 日本边添边摸边做边爱| 午夜精品久久久久久久爽| 无码国产一区二区三区四区| 欧美三级在线播放线观看| 中国女人内谢69xxxx视频| 国产寡妇偷人在线观看| 日本19禁啪啪吃奶大尺度| 亚洲精品乱码久久久久久v| 无码人中文字幕| 国产精品特黄aaaa片在线观看 | 国产一区二区三区免费观看在线 | 成人亚洲a片v一区二区三区蜜臀| 久久99日韩国产精品久久99| 国产精品免费视频网站| 一本一道色欲综合网中文字幕| a毛片免费全部播放自慰| 国产又黄又爽又色的免费视频 | 又粗又大内射免费视频小说| 成人精品一区日本无码网站|