在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCC Antibody, HRP conjugated

MCC Antibody, HRP conjugated

  • 中文名稱：
    MCC兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA013571LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MCC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCC
  • 別名：
    Colorectal mutant cancer protein antibody; CRCM_HUMAN antibody; DKFZp762O1615 antibody; FLJ38893 antibody; FLJ46755 antibody; MCC 1 antibody; MCC antibody; MCC1 antibody; Mutated in colorectal cancers antibody; Protein MCC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Colorectal mutant cancer protein (479-611AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.
  • 基因功能參考文獻：
    1. Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin mediated cell-cell adhesion in colorectal cancer cells. PMID: 29035389
    2. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID: 29144123
    3. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression. PMID: 27226254
    4. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells PMID: 25200342
    5. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 PMID: 24824780
    6. targeted by miR-494, which is overexpressed in hepatocellular carcinoma PMID: 23913442
    7. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex. PMID: 22480440
    8. we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci. PMID: 22542170
    9. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer. PMID: 22213290
    10. observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population PMID: 21279955
    11. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction. PMID: 18591935
    12. Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2. PMID: 19555689

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.
  • 蛋白家族：
    MCC family
  • 組織特異性：
    Expressed in a variety of tissues.
  • 數據庫鏈接：

    HGNC: 6935

    OMIM: 159350

    KEGG: hsa:4163

    STRING: 9606.ENSP00000386227

    UniGene: Hs.593171



主站蜘蛛池模板： 久久久久国产精品人妻aⅴ牛牛| 国产成人高清精品免费| 国产成人亚洲综合网站小说 | 久久综合九色欧美婷婷| 日本高清无卡码一区二区| 无码精品一区二区三区免费视频| 中国免费看的片| 中文国产成人精品久久不卡| 国产嫖妓一区二区三区无码| 免费高清av一区二区三区| 欧美xxxxx在线观看| 最近最新中文字幕高清免费| www插插插无码免费视频网站| 国内精品国产成人国产三级| 亚洲午夜成人久久久久久| 久久国产精久久精产国| 久久久亚洲精品一区二区三区| 中国美女毛茸茸撒尿| 精品少妇人妻av一区二区三区| 在线看片免费人成视频福利| 曰本一道本久久88不卡| 日本丰满少妇bbb| 高清不卡一区二区三区| 少妇放荡的呻吟干柴烈火动漫| 亚洲成av人片不卡无码久久| 伊人大杳焦在线| 无码人妻黑人中文字幕| 超碰97人人射妻| 四虎成人精品无码永久在线| 2021国产精品国产精华| 2022一本久道久久综合狂躁| 人人人妻人人澡人人爽欧美一区| 伊人久久五月丁香综合中文亚洲| 国产在线精品一区二区三区直播| 视频二区丝袜国产欧美日韩| 国产一码二码三码区别| 成片免费观看视频大全| 天天摸夜夜添狠狠添高潮出水| 2021久久国自产拍精品| 国产精品99精品无码视亚 | 国产极品视觉盛宴|