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MATK Antibody

  • 中文名稱:
    MATK兔多克隆抗體
  • 貨號:
    CSB-PA010068
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CHK antibody; Csk homologous kinase antibody; Csk type protein tyrosine kinase antibody; CTK antibody; DKFZp434N1212 antibody; EC 2.7.10.2 antibody; Hematopoietic consensus tyrosine lacking kinase antibody; Hematopoietic consensus tyrosine-lacking kinase antibody; HHYLTK antibody; Hydroxyaryl protein kinase antibody; HYL antibody; HYL tyrosine kinase antibody; HYLTK antibody; Leukocyte carboxyl terminal src kinase related antibody; Lsk antibody; matK antibody; MATK_HUMAN antibody; Megakaryocyte associated tyrosine kinase antibody; Megakaryocyte associated tyrosine protein kinase antibody; Megakaryocyte-associated tyrosine-protein kinase antibody; MGC1708 antibody; MGC2101 antibody; Protein kinase HYL antibody; Tyrosine kinase MATK antibody; Tyrosine protein kinase CTK antibody; Tyrosine-protein kinase CTK antibody; Tyrosylprotein kinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Lsk.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
  • 基因功能參考文獻:
    1. After IGF-I stimulation, CTK is recruited to IGF-IR and its recruitment facilitates CTK's subsequent association with phospho-SHPS-1. PMID: 21799000
    2. ERBB2 binds to the SH2 domain of CHK and inhibits cell growth in human breast tumor cell lines PMID: 12122014
    3. Overexpression of the Csk homologous kinase facilitates phosphorylation of akt/protein kinase b in breast neoplasms PMID: 12429987
    4. CHK Leu223 stabilizes the movement of the alphaC-helix of the protein tyrosine kinase PMID: 12782282
    5. Loss of CHK expression is associated with human brain tumors PMID: 15329911
    6. Nuclear multi-lobulation in late S phase, which is dependent on polymerization and depolymerization of microtubules, may be involved in nuclear Chk-induced inhibition of proliferation. PMID: 15748901
    7. striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains PMID: 15890649
    8. This study describes for the first time the Src-independent actions of CHK and provides novel insights into CHK function in neural cells. PMID: 16168623
    9. Matk/CHK is not functionally redundant with Csk, and this tyrosine kinase plays an important role as a regulator of immunologic responses PMID: 16574955
    10. Findings indicate that the importance of the N-terminal domain to Chk-induced tyrosine phosphorylation in the nucleus, and implicate that nuclear tyrosine-phosphorylated proteins may contribute to inhibition of cell proliferation. PMID: 16707123
    11. Progesterone increases MATK in mast cells and reducs cell proliferation. PMID: 17492661
    12. These results reveal a potentially important role for CHK in Src activation and tumorigenicity in colon cancer cells. PMID: 17934522
    13. CHK is capable of inhibiting the CXCL12-CXCR4 pathway in neuroblastoma. PMID: 18292939

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  • 亞細胞定位:
    Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSK subfamily
  • 組織特異性:
    Expressed in various myeloid cell lines, detected in brain and lung.
  • 數據庫鏈接:

    HGNC: 6906

    OMIM: 600038

    KEGG: hsa:4145

    STRING: 9606.ENSP00000378485

    UniGene: Hs.631845



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