在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAP3K4 Antibody, HRP conjugated

  • 中文名稱:
    MAP3K4兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA013426LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MAP3K4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody; FLJ42439 antibody; KIAA0213 antibody; M3K4_HUMAN antibody; MAP three kinase 1 antibody; MAP/ERK kinase kinase 4 antibody; MAP3K4 antibody; MAPK/ERK kinase kinase 4 antibody; MAPKKK4 antibody; MEK kinase 4 antibody; MEKK 4 antibody; MEKK4 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MTK1 antibody; predicted protein of HQ0412 antibody; PRO0412 antibody; RP3-473J16.4 antibody; SSK2/SSK22 MAP kinase kinase kinase; yeast; homolog of antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Mitogen-activated protein kinase kinase kinase 4 protein (53-145AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
  • 基因功能參考文獻(xiàn):
    1. IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma PMID: 26802931
    2. Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. PMID: 25173755
    3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal. PMID: 24452333
    4. MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. PMID: 24036211
    5. MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells. PMID: 23760366
    6. we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease. PMID: 22732089
    7. For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. PMID: 22309839
    8. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
    9. MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway PMID: 16157600
    10. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
    11. In this review, the role of MKK4 in cancer development appears complex, as some studies support a pro-oncogenic role for MKK4, while others suggest it may have tumor suppressor functions. PMID: 17496914

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, perinuclear region.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性:
    Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6856

    OMIM: 602425

    KEGG: hsa:4216

    STRING: 9606.ENSP00000375986

    UniGene: Hs.390428



主站蜘蛛池模板: 亚洲人成色77777| 国产成人亚洲精品无码电影| 亚洲精品制服丝袜四区| 国内精品乱码卡一卡2卡| 久久久综综合色一本伊人| 东北老女人高潮大叫对白| 国产精品久久久久久爽爽爽| 一线二线无人区乱码| 日韩人妻潮喷中文在线视频| 精品伊人久久久大香线蕉下载| 亚洲女人被黑人巨大进入| 日日橹狠狠爱欧美超碰| 真实国产乱子伦视频| 久久理论片午夜琪琪电影网| 国产综合久久亚洲综合| 欧美日韩一区二区综合| 国产精品人妻| 亚洲aⅴ永久无码一区二区三区 | 国产在线一区二区在线视频 | 老司机在线精品视频播放| 亚洲中文字幕久久无码| 亚洲aⅴ综合色区无码一区| 日日婷婷夜日日天干| 强 暴 疼 哭 处 女 身子视频| 中文字幕亚洲欧美在线不卡| 精品国产一区二区三区四区vr| 国模大尺度啪啪| 国产精品女人呻吟在线观看| 骚动漫十八禁在线观看| 北条麻妃在线一区二区| av午夜久久蜜桃传媒软件| 亚洲综合熟女久久久40p| 99热网址最新获取域名| 天天躁日日躁狠狠躁av中文| 亚洲精品久久久久久一区二区| 免费国产va在线观看| 欧美性猛交xxxxx按摩欧美| 特黄做受又粗又大又硬老头| 亚洲天堂男人影院| 色综合久久中文娱乐网| 韩国的无码av看免费大片在线|