在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MAP3K4 Antibody, Biotin conjugated

MAP3K4 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    MAP3K4兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA013426LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) MAP3K4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody; FLJ42439 antibody; KIAA0213 antibody; M3K4_HUMAN antibody; MAP three kinase 1 antibody; MAP/ERK kinase kinase 4 antibody; MAP3K4 antibody; MAPK/ERK kinase kinase 4 antibody; MAPKKK4 antibody; MEK kinase 4 antibody; MEKK 4 antibody; MEKK4 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MTK1 antibody; predicted protein of HQ0412 antibody; PRO0412 antibody; RP3-473J16.4 antibody; SSK2/SSK22 MAP kinase kinase kinase; yeast; homolog of antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase kinase kinase 4 protein (53-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
  • 基因功能參考文獻(xiàn)：
    1. IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma PMID: 26802931
    2. Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. PMID: 25173755
    3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal. PMID: 24452333
    4. MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. PMID: 24036211
    5. MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells. PMID: 23760366
    6. we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease. PMID: 22732089
    7. For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. PMID: 22309839
    8. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
    9. MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway PMID: 16157600
    10. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
    11. In this review, the role of MKK4 in cancer development appears complex, as some studies support a pro-oncogenic role for MKK4, while others suggest it may have tumor suppressor functions. PMID: 17496914

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性：
    Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6856

    OMIM: 602425

    KEGG: hsa:4216

    STRING: 9606.ENSP00000375986

    UniGene: Hs.390428



主站蜘蛛池模板： 国产精品点击进入在线影院高清| 国产av一区二区精品凹凸| 人妻少妇精品视频无码专区| 夜晚成人18禁区导航网站| 无码免费h成年动漫在线观看| 玖玖资源站无码专区| 国产无遮挡又黄又爽高潮| 日日躁夜夜躁狠狠久久av| 中文字幕久久熟女蜜桃| 亚洲精品国精品久久99热| 亚洲国产欧美在线人成人| 中文字幕丰满乱子无码视频| 亚洲综合另类小说色区大陆| 成人无码精品一区二区三区亚洲区| 午夜不卡久久精品无码免费| 性无码专区无码片| 亚洲国产精品一区二区手机| 亚欧日韩欧美网站在线看| 欧美日韩在线视频一区| 无码人妻啪啪一区二区| 成年午夜精品久久久精品| 国产精品夜夜春夜夜爽久久| 国产精品∧v在线观看| 国产精品久久久久久av| 成在线人免费无码高潮喷水| 人妻少妇乱子伦精品| 伊人久久大香线蕉av仙人| 全国最大成人网| 色一情一区二区三区四区| 久久日本三级韩国三级| av天堂中av世界中文在线播放| 欧美高清大屁股xxxxx| 亚洲日韩国产av无码无码精品| 99久久综合狠狠综合久久| 日韩精品人妻无码久久影院| 亚洲国产精品无码久久秋霞| 亚洲女人被黑人巨大进入| 少妇人妻av毛片在线看| 久久国产福利一区二区| 亚洲五月色丁香婷婷婷| 亚洲成av人片在线观看www|