在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAP3K4 Antibody, FITC conjugated

  • 中文名稱:
    MAP3K4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA013426LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAP3K4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody; FLJ42439 antibody; KIAA0213 antibody; M3K4_HUMAN antibody; MAP three kinase 1 antibody; MAP/ERK kinase kinase 4 antibody; MAP3K4 antibody; MAPK/ERK kinase kinase 4 antibody; MAPKKK4 antibody; MEK kinase 4 antibody; MEKK 4 antibody; MEKK4 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MTK1 antibody; predicted protein of HQ0412 antibody; PRO0412 antibody; RP3-473J16.4 antibody; SSK2/SSK22 MAP kinase kinase kinase; yeast; homolog of antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Mitogen-activated protein kinase kinase kinase 4 protein (53-145AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
  • 基因功能參考文獻:
    1. IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma PMID: 26802931
    2. Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. PMID: 25173755
    3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal. PMID: 24452333
    4. MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. PMID: 24036211
    5. MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells. PMID: 23760366
    6. we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease. PMID: 22732089
    7. For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. PMID: 22309839
    8. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
    9. MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway PMID: 16157600
    10. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
    11. In this review, the role of MKK4 in cancer development appears complex, as some studies support a pro-oncogenic role for MKK4, while others suggest it may have tumor suppressor functions. PMID: 17496914

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性:
    Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
  • 數據庫鏈接:

    HGNC: 6856

    OMIM: 602425

    KEGG: hsa:4216

    STRING: 9606.ENSP00000375986

    UniGene: Hs.390428



主站蜘蛛池模板: 无码午夜福利视频1000集 | 久久精品人人槡人妻人| 亚洲高潮喷水无码av电影| 女人被爽到高潮视频免费国产| 中文有码亚洲制服av片| 一边摸一边抽搐一进一出视频| 无码精品一区二区三区在线| 人妻免费一区二区三区最新| 成 人 a v免费视频在线观看 | 一道本在线伊人蕉无码| 久久精品天天中文字幕人妻| 国产精品久久福利网站| 黄网站色视频免费观看| 亚洲第一福利网站在线观看| 欧洲精品久久久av无码电影| 97国产精东麻豆人妻电影| 亚洲国产精品日本无码网站| 巨爆乳中文字幕巨爆区巨爆乳无码| 中文字幕亚韩| av在线亚洲男人的天堂| 无码国模大尺度视频在线观看| mm1313亚洲国产精品无码试看| 呦系列视频一区二区三区 | 97在线视频人妻无码| 麻豆果冻国产剧情av在线播放| 亚洲爆乳成av人在线视水卜| 一个人看的免费高清www视频| 50路60路老熟妇啪啪| 黄网站色视频免费国产| 亚洲精品乱拍国产一区二区三区| 99国产精品久久99久久久| 强开小婷嫩苞又嫩又紧视频韩国| 一道精品视频一区二区三区| 亚洲第一无码av无码专区| 一本大道无码人妻精品专区| 9re热国产这里只有精品| 亚洲а∨天堂久久精品| 亚洲国产精品一区二区美利坚| 无码人妻一区二区三区免费| 久久青青草原精品国产app| 老头把我添高潮了a片|