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  4. MAGED2 Antibody, Biotin conjugated

MAGED2 Antibody, Biotin conjugated

  • 中文名稱：
    MAGED2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA891976LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MAGED2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MAGED2
  • 別名：
    11B6 antibody; BCG 1 antibody; BCG-1 antibody; Breast cancer-associated gene 1 protein antibody; HCA10 antibody; Hepatocellular carcinoma-associated protein JCL-1 antibody; JCL 1 antibody; MAGD2_HUMAN antibody; MAGE D antibody; MAGE D2 antigen antibody; MAGE-D2 antigen antibody; MAGED2 antibody; Melanoma antigen family D 2 antibody; Melanoma associated antigen D2 antibody; Melanoma-associated antigen D2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Melanoma-associated antigen D2 protein (38-285AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
  • 基因功能參考文獻：
    1. Increased expression of MAGE-D2 mRNA was associated with distant metastasis in Gastric Cancer. PMID: 25743330
    2. MAGE-D2 is a dynamic protein whose shuttling properties could suggest a role in cell cycle regulation. PMID: 26705694
    3. We found that MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter's syndrome. PMID: 27120771
    4. these results identify the expression of MAGE-D2 suppresses TRAIL receptor 2 and protects againstas TRAIL-induced apoptosis PMID: 22791814
    5. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues PMID: 11856887
    6. Maged2 is mainly expressed in tissues of mesodermal origin PMID: 15162511
    7. Results identified a cDNA clone, corresponding to MAGE D2 mRNA, from primary human bronchial epithelial cells which exhibits increased expression in vitro after treatment with all-trans retinoic acid. PMID: 15465002
    8. MAGED2, a novel protein, is a p53-dissociator. PMID: 17912449

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  • 相關疾病：
    Bartter syndrome 5, antenatal, transient (BARTS5)
  • 組織特異性：
    Widely expressed. In the developing and adult kidney, expressed in the thick ascending limb of the loop of Henle and the distal convoluted tubules outside the loop.
  • 數據庫鏈接：

    HGNC: 16353

    OMIM: 300470

    KEGG: hsa:10916

    STRING: 9606.ENSP00000218439

    UniGene: Hs.522665



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