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  4. LSS Antibody

LSS Antibody

  • 中文名稱：
    LSS兔多克隆抗體
  • 貨號：
    CSB-PA013216ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: LSS antibody at 0.76μg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to Rabbit IgG at 1/10000 dilution
      Predicted band size: 84, 75, 83 kDa
      Observed band size: 83 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA013216ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LSS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LSS
  • 別名：
    LSS antibody; OSCLanosterol synthase antibody; EC 5.4.99.7 antibody; 2,3-epoxysqualene--lanosterol cyclase antibody; Oxidosqualene--lanosterol cyclase antibody; OSC antibody; hOSC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Lanosterol synthase protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
  • 基因功能參考文獻：
    1. LSS gene mutation is associated with Congenital cataract. PMID: 29016354
    2. Lanosterol synthase gene polymorphisms influence both the salt sensitivity of BP and changes in circulating EO in response to a low salt diet. PMID: 26667413
    3. There were no significant differences in OSC mRNA expression at various stages of breast cancer, or between tumor and normal mammary cells. PMID: 25051231
    4. oxidosqualene cyclase is active as a monomer PMID: 14766201
    5. two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors PMID: 15525992
    6. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. PMID: 19119143

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  • 相關疾病：
    Cataract 44 (CTRCT44)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    Terpene cyclase/mutase family
  • 組織特異性：
    Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
  • 數據庫鏈接：

    HGNC: 6708

    OMIM: 600909

    KEGG: hsa:4047

    STRING: 9606.ENSP00000348762

    UniGene: Hs.596543



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