在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LEO1 Antibody

  • 中文名稱:
    LEO1兔多克隆抗體
  • 貨號:
    CSB-PA845150NA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA845150NA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate
      All lanes: LEO1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 76, 69 kDa
      Observed band size: 76 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LEO1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LEO1
  • 別名:
    Gm185 antibody; LEO1 antibody; LEO1_HUMAN antibody; LOC123439 antibody; Paf1/RNA polymerase II complex component antibody; Replicative senescence down regulated leo1 like protein antibody; Replicative senescence down-regulated leo1-like protein antibody; Replicative senescence downregulated leo1 like antibody; RNA polymerase associated protein LEO1 antibody; RNA polymerase-associated protein LEO1 antibody; Senescence downregulated leo1 like antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human RNA polymerase-associated protein LEO1 protein (2-24AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,LEO1 Antibody (CSB-PA845150NA01HU),的標記方式是Non-conjugated。對于LEO1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA845150NB01HU LEO1 Antibody, HRP conjugated ELISA
    FITC CSB-PA845150NC01HU LEO1 Antibody, FITC conjugated
    Biotin CSB-PA845150ND01HU LEO1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
  • 基因功能參考文獻:
    1. PRL-3 and Leo1 levels were positively associated in AML patient samples. PMID: 24686170
    2. Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified. PMID: 20196086
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    LEO1 family
  • 組織特異性:
    Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
  • 數據庫鏈接:

    HGNC: 30401

    OMIM: 610507

    KEGG: hsa:123169

    STRING: 9606.ENSP00000299601

    UniGene: Hs.567662



主站蜘蛛池模板: 日日碰狠狠添天天爽五月婷| 中文字幕丰满伦子无码| 日韩人妻无码精品专区综合网| 天天综合爱天天综合色| 精品人妻av区乱码| 亚洲偷自拍国综合| 被窝影院午夜无码国产| 亚洲 欧美 中文 日韩aⅴ| 国产综合久久久久久鬼色| 蜜桃视频一区二区在线观看| 成年片色大黄全免费软件到| 免费无码在线播放av | 国产疯狂伦交大片| 99久久婷婷国产综合精品电影| 精品久久久久中文字幕加勒比| 亚洲精品国产美女久久久99| 亚洲一区二区三区四区五区六区 | 成人国内精品久久久久一区| 18禁黄污吃奶免费看网站| 免费看又黄又爽又猛的视频软件| 亚洲日韩国产中文其他| 热99re久久精品这里都是精品| 日韩一本之道一区中文字幕| 又爽又色禁片1000视频免费看 | 人妻换人妻仑乱| 欧美日韩在手机线旡码可下载| 久久精品99国产精品日本| 色综合久久久久久久久久| 野外少妇被弄到喷水在线观看| 亚洲国产精品一区二区制服| 欧美伊人久久大香线蕉综合| 精品无码一区二区三区爱欲| 又黄又湿啪啪响18禁| 毛片免费视频| 日本亲与子乱人妻hd| 少妇性荡欲视频| 亚洲高清毛片一区二区| 国产精品久久久久久影视 | 国产青草视频在线观看| 夜夜添无码试看一区二区三区| 色悠久久久久综合网国产|