在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LEO1 Antibody

  • 中文名稱:
    LEO1兔多克隆抗體
  • 貨號:
    CSB-PA233075
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA233075(LEO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA233075(LEO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LEO1
  • 別名:
    Gm185 antibody; LEO1 antibody; LEO1_HUMAN antibody; LOC123439 antibody; Paf1/RNA polymerase II complex component antibody; Replicative senescence down regulated leo1 like protein antibody; Replicative senescence down-regulated leo1-like protein antibody; Replicative senescence downregulated leo1 like antibody; RNA polymerase associated protein LEO1 antibody; RNA polymerase-associated protein LEO1 antibody; Senescence downregulated leo1 like antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Synthetic peptide of Human LEO1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
  • 基因功能參考文獻:
    1. PRL-3 and Leo1 levels were positively associated in AML patient samples. PMID: 24686170
    2. Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified. PMID: 20196086
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    LEO1 family
  • 組織特異性:
    Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
  • 數據庫鏈接:

    HGNC: 30401

    OMIM: 610507

    KEGG: hsa:123169

    STRING: 9606.ENSP00000299601

    UniGene: Hs.567662



主站蜘蛛池模板: 国产18禁黄网站免费观看| 3d动漫精品啪啪一区二区 | 久热这里在线精品| 精品无人乱码高清在线观看| av色综合久久天堂av色综合| 影视先锋av资源噜噜| 337p日本欧洲亚洲大胆色噜噜| 亚洲中文字幕婷婷在线| 日韩卡1卡2 卡三卡免费| 麻豆人妻无码性色av专区| 国产在线精品一区在线观看| 国产精品丝袜一区二区三区| 亚洲精品亚洲人成在线观看| 97久久婷婷五月综合色d啪蜜芽| 久久久国产99久久国产久一| 66lu国产在线观看| 日本精品少妇一区二区三区| 成人h动漫精品一区二区| 天干天干夜啦天干天干国产| 手机真实国产乱子伦对白视频| 亚洲午夜久久久影院伊人| 国产精品美脚玉足脚交欧美| 午夜福利啪啪无遮挡免费| 久久激情五月丁香伊人| 日本无遮挡吸乳视频| 色综合久久久久久久久久| 人人玩人人添人人澡超碰偷拍| 人人澡人人妻人人爽人人蜜桃麻豆 | 日本丰满熟妇videossex8k| 免费观看的av在线播放| 在线观看免费人成视频网| 又黄又爽的60分钟视频| 久久精品国产av一区二区三区| 狂野欧美性猛xxxx乱大交 | 亚洲精品国产一区二区图片| 亚洲精品成a人在线观看| 国产在线精品一区二区| 浪荡女天天不停挨cao日常视频| 亚洲自偷自拍另类小说| 亚洲v欧美v国产v在线观看| 亚洲欧美日本韩国|