在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LEO1 Antibody

  • 中文名稱:
    LEO1兔多克隆抗體
  • 貨號:
    CSB-PA233075
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA233075(LEO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA233075(LEO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LEO1
  • 別名:
    Gm185 antibody; LEO1 antibody; LEO1_HUMAN antibody; LOC123439 antibody; Paf1/RNA polymerase II complex component antibody; Replicative senescence down regulated leo1 like protein antibody; Replicative senescence down-regulated leo1-like protein antibody; Replicative senescence downregulated leo1 like antibody; RNA polymerase associated protein LEO1 antibody; RNA polymerase-associated protein LEO1 antibody; Senescence downregulated leo1 like antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Synthetic peptide of Human LEO1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
  • 基因功能參考文獻:
    1. PRL-3 and Leo1 levels were positively associated in AML patient samples. PMID: 24686170
    2. Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified. PMID: 20196086
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    LEO1 family
  • 組織特異性:
    Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
  • 數據庫鏈接:

    HGNC: 30401

    OMIM: 610507

    KEGG: hsa:123169

    STRING: 9606.ENSP00000299601

    UniGene: Hs.567662



主站蜘蛛池模板: 国产毛片久久久久久国产毛片 | 无遮挡男女激烈动态图| 亚洲国内成人精品网| 一区二区三区无码高清视频| 国产熟妇与子伦hd| 精品自拍亚洲一区在线| 丁香狠狠色婷婷久久综合| 亚洲 欧美 日韩 综合aⅴ视频| 97se亚洲精品一区| av无码东京热亚洲男人的天堂| 天堂网www天堂资源网| 久久精品一区二区免费播放| 国产成人av在线影院| 欧美成人综合久久精品| 三级无码在钱av无码在钱| 国产一卡2卡3卡4卡精品| 国产精品久久久久久2021| 亚洲日韩精品欧美一区二区| 国产av精品毛片一区二区三区 | 久久天天躁狠狠躁夜夜2019| 黄桃av无码免费一区二区三区| 欧美国产日产一区二区| 综合无码精品人妻一区二区三区| 久久久综合九色合综| 毛片免费视频肛交颜射免费视频 | 羞羞色男人的天堂| 韩国午夜福利片在线| 欧美性潮喷xxxxx免费视频看| 亚洲精品久久久久久一区二区 | 国产精品成人国产乱| 香蕉伊蕉伊中文视频在线| 狠狠色老熟妇老熟女| 在线 v亚洲 v欧美v 专区| 巨大黑人极品videos精品| 98视频精品全部国产| 成人性无码专区免费视频| 成人艳情一二三区| 成人免费视频在线观看| 国产成人av综合久久视色| 性按摩玩人妻hd中文字幕| 中国国语毛片免费观看视频|