在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LARS Antibody

LARS Antibody

  • 中文名稱：
    LARS兔多克隆抗體
  • 貨號：
    CSB-PA873736LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Raji whole cell lysate, U251 whole cell lysate
      All lanes: LARS antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 135, 129, 56 kDa
      Observed band size: 135 kDa
    • IHC image of CSB-PA873736LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA873736LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LARS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LARS
  • 別名：
    cytoplasmic antibody; Cytoplasmic leucyl tRNA synthetase antibody; Cytosolic leucyl tRNA synthetase antibody; FLJ10595 antibody; FLJ21788 antibody; hr025Cl antibody; HSPC 192 antibody; HSPC192 antibody; KIAA1352 antibody; LARS 1 antibody; Lars antibody; LARS1 antibody; Leucine translase antibody; Leucine tRNA ligase antibody; Leucine--tRNA ligase antibody; Leucyl tRNA synthetase cytoplasmic antibody; Leucyl-tRNA synthetase antibody; LeuRS antibody; LEUS antibody; LRS antibody; PIG 44 antibody; PIG44 antibody; Proliferation inducing gene 44 antibody; RNTLS antibody; SYLC_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine--tRNA ligase, cytoplasmic protein (614-892AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，LARS Antibody (CSB-PA873736LA01HU)，的標(biāo)記方式是Non-conjugated。對于LARS Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA873736LB01HU LARS Antibody, HRP conjugated ELISA
    FITC CSB-PA873736LC01HU LARS Antibody, FITC conjugated
    Biotin CSB-PA873736LD01HU LARS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
  • 基因功能參考文獻(xiàn)：
    1. Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. PMID: 28963468
    2. The results showed a decrease in autophagy on addition of leucine, demonstrating crosstalk between leucine sensing, LRS translocation, RagD interaction, and mTORC1 activation. PMID: 28882589
    3. the KMSKS catalytic loop affects the aminoacylation and editing capacities of leucyl-tRNA synthetase PMID: 25817995
    4. Lack of a CP1 hairpin in LeuRS led to complete loss of aminoacylation, amino acid activation, and tRNA binding; however, the mutants retained post-transfer editing. PMID: 25051973
    5. the carboxy-terminal domain of human mitochondrial (mt) leucyl-tRNA synthetase can be used to correct mt dysfunctions caused by mt-tRNA mutations. PMID: 24413190
    6. Identification of a mutation in LARS as a novel cause of infantile hepatopathy PMID: 22607940
    7. This work demonstrates that LRS is a key mediator for amino acid signaling to mTORC1. PMID: 22424946
    8. hcLeuRS can charge RNALeu with non-cognate amino acids and exclude the incorrect products by multiple editing pathways. PMID: 20805241
    9. leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex PMID: 16055448
    10. We identified a novel G3283A transition in the mitochondrial DNA tRNA(Leu (UUR)) gene in a patient with ptosis, ophthalmoparesis and hyporeflexia. PMID: 17363246
    11. Results show that K600 in human leucyl-tRNA synthetase affects amino acid specificity and tRNA aminoacylation. PMID: 17378584
    12. findings suggest that LARS1 may play roles in migration and growth of lung cancer cells, which suggest its potential implication in lung tumorigenesis PMID: 18446061
    13. Study of crystal structures of the editing domain from 2 eukaryotic cytosolic LeuRS; shows a conserved structural core containing the active site for hydrolysis, with distinct bacterial, archeal, or eukaryotic peripheral insertions. PMID: 19426743
    14. the introduction of bulky residues into the amino acid binding pocket failed to block deacylation of tRNA, indicating that the architecture of the amino acid binding pocket is different compared to that of other characterized LeuRSs PMID: 19702327

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Infantile liver failure syndrome 1 (ILFS1)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6512

    OMIM: 151350

    KEGG: hsa:51520

    STRING: 9606.ENSP00000377954

    UniGene: Hs.432674



主站蜘蛛池模板： 欧美高清精品一区二区| 国产9 9在线 | 欧洲| 国产精品美女久久久| 久久久国产精品亚洲一区| 成人无码精品一区二区三区| 亚洲成亚洲成网| 无码人妻精品一二三区免费| 欧美色综合天天久久综合精品 | 欧洲美女粗暴牲交免费观看| 日本伊人色综合网| 国产成人精品福利一区二区三区| 成人看片黄a免费看| 色妞www精品视频| 中字幕人妻一区二区三区| 特级欧美插插插插插bbbbb| 日本丰满少妇bbb| 1000部拍拍拍18勿入免费视频下载 | 亚洲国产v高清在线观看| 7777奇米成人狠狠成人影视| 狠狠噜天天噜日日噜| 亚洲人成精品久久久久| 99九九99九九视频精品| 午夜无码成人免费视频| 强行糟蹋人妻hd中文字| 无遮挡十八禁污污网站免费| 国产肉丝袜视频在线观看| 欧美 日韩 国产 亚洲 色| 又粗又黄又硬又爽的免费视频| 国产在线看片免费观看| 国产区精品福利在线社区| 亚洲精品国产一区二区| 日韩国产亚洲欧美中国v| 五月激情婷婷丁香综合基地| 大陆极品少妇内射aaaaaa| 欧牲交a欧美牲交aⅴ| 成年女人看片永久免费视频| √天堂中文官网8在线| 精品人妻伦九区久久aaa片69| 香蕉97超级碰碰碰免费公开| 亚洲精品国偷拍自产在线观看蜜桃| 女人的精水喷出来视频|