在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LARS Antibody, Biotin conjugated

  • 中文名稱:
    LARS兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA873736LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LARS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LARS
  • 別名:
    cytoplasmic antibody; Cytoplasmic leucyl tRNA synthetase antibody; Cytosolic leucyl tRNA synthetase antibody; FLJ10595 antibody; FLJ21788 antibody; hr025Cl antibody; HSPC 192 antibody; HSPC192 antibody; KIAA1352 antibody; LARS 1 antibody; Lars antibody; LARS1 antibody; Leucine translase antibody; Leucine tRNA ligase antibody; Leucine--tRNA ligase antibody; Leucyl tRNA synthetase cytoplasmic antibody; Leucyl-tRNA synthetase antibody; LeuRS antibody; LEUS antibody; LRS antibody; PIG 44 antibody; PIG44 antibody; Proliferation inducing gene 44 antibody; RNTLS antibody; SYLC_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Leucine--tRNA ligase, cytoplasmic protein (614-892AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
  • 基因功能參考文獻:
    1. Leucyl-tRNA synthetase (LRS) is a leucine sensor of the mTORC1 pathway. PMID: 28963468
    2. The results showed a decrease in autophagy on addition of leucine, demonstrating crosstalk between leucine sensing, LRS translocation, RagD interaction, and mTORC1 activation. PMID: 28882589
    3. the KMSKS catalytic loop affects the aminoacylation and editing capacities of leucyl-tRNA synthetase PMID: 25817995
    4. Lack of a CP1 hairpin in LeuRS led to complete loss of aminoacylation, amino acid activation, and tRNA binding; however, the mutants retained post-transfer editing. PMID: 25051973
    5. the carboxy-terminal domain of human mitochondrial (mt) leucyl-tRNA synthetase can be used to correct mt dysfunctions caused by mt-tRNA mutations. PMID: 24413190
    6. Identification of a mutation in LARS as a novel cause of infantile hepatopathy PMID: 22607940
    7. This work demonstrates that LRS is a key mediator for amino acid signaling to mTORC1. PMID: 22424946
    8. hcLeuRS can charge RNALeu with non-cognate amino acids and exclude the incorrect products by multiple editing pathways. PMID: 20805241
    9. leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex PMID: 16055448
    10. We identified a novel G3283A transition in the mitochondrial DNA tRNA(Leu (UUR)) gene in a patient with ptosis, ophthalmoparesis and hyporeflexia. PMID: 17363246
    11. Results show that K600 in human leucyl-tRNA synthetase affects amino acid specificity and tRNA aminoacylation. PMID: 17378584
    12. findings suggest that LARS1 may play roles in migration and growth of lung cancer cells, which suggest its potential implication in lung tumorigenesis PMID: 18446061
    13. Study of crystal structures of the editing domain from 2 eukaryotic cytosolic LeuRS; shows a conserved structural core containing the active site for hydrolysis, with distinct bacterial, archeal, or eukaryotic peripheral insertions. PMID: 19426743
    14. the introduction of bulky residues into the amino acid binding pocket failed to block deacylation of tRNA, indicating that the architecture of the amino acid binding pocket is different compared to that of other characterized LeuRSs PMID: 19702327

    顯示更多

    收起更多

  • 相關疾病:
    Infantile liver failure syndrome 1 (ILFS1)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class-I aminoacyl-tRNA synthetase family
  • 數據庫鏈接:

    HGNC: 6512

    OMIM: 151350

    KEGG: hsa:51520

    STRING: 9606.ENSP00000377954

    UniGene: Hs.432674



主站蜘蛛池模板: 天堂资源中文最新版在线一区| 天堂在线中文| 无码成人一区二区三区| 国产a√精品区二区三区四区| 真实人与人性恔配视频| 在线天堂资源www| 国产精品久久无码一区| 精品无码久久久久久久久| 亚洲高清成人av电影网站 | 久久久久女人精品毛片| 日本高清色www网站色噜噜噜 | 亚洲成在人线在线播放无码vr| 久久麻豆成人精品av| 久久精品aⅴ无码中文字字幕重口 亚洲精品永久在线观看 | 青娱乐极品视觉盛宴av| 永久久久免费人妻精品| 国产日产欧美最新| 精品国产一区二区三区四区vr| 久久久www成人免费精品| 日韩加勒比一本无码精品| 国产成_人_综合_亚洲_国产| 国产一区二区三区久久精品| 亚洲色欲www综合网| 久久久女人与动物群交毛片| 国产精品久久久久久久久久妞妞| 中文字幕日本人妻久久久免费| 久久不见久久见www免费| 制服丝袜亚洲欧美中文字幕| 131美女爱做视频免费| 欧美激情综合五月色丁香| 精品国产麻豆免费人成网站| 欧美伦费免费全部午夜最新| 亚洲色一区二区三区四区| 新婚少妇无套内谢国语播放| 在线观看高h无码黄动漫| 一区一区三区产品乱码| 国产精品无码无在线观看| 国产精品视频一区二区亚瑟| 欧美3p两根一起进高清视频| 国产又黄又爽又猛免费视频播放| 少妇仑乱a毛片无码|