在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT6A Antibody

  • 中文名稱:
    KRT6A兔多克隆抗體
  • 貨號:
    CSB-PA012561ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KRT6A antibody at 5.82 μg/ml
      Lane 1: Mouse lung tissue
      Lane 2: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA012561ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KRT6A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KRT6A
  • 別名:
    CK-6A antibody; CK-6D antibody; CK6A antibody; CK6C antibody; CK6D antibody; Cytokeratin-6A antibody; Cytokeratin-6D antibody; K2C6A_HUMAN antibody; K6A antibody; K6C antibody; K6D antibody; keratin 6A antibody; Keratin antibody; Keratin; type II cytoskeletal 6A antibody; Keratin-6A antibody; Krt6a antibody; KRT6C antibody; KRT6D antibody; type II cytoskeletal 6A antibody; Type-II keratin Kb6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Keratin, type II cytoskeletal 6A protein (305-564AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
  • 基因功能參考文獻:
    1. Manipulating K6a phosphorylation or ubiquitin-proteasome system (UPS) activity may provide opportunities to harness the innate immunity of epithelia against infection. PMID: 29191848
    2. Several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries. PMID: 29357356
    3. KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia. PMID: 27041546
    4. we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis. PMID: 24708461
    5. Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens. PMID: 23006328
    6. Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A need further studies to confirm the rare feature of fissured tongue PMID: 22668561
    7. We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations. PMID: 22264670
    8. Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system. PMID: 22098151
    9. This report is the first case of pachyonychia congenita with laryngeal obstruction in which the gene mutation has been established (a deletional mutation in keratin 6a). PMID: 21554383
    10. Focal palmoplantar keratoderma is associated with mutations in keratin K6c in 3 families. 2 unrelated families have Asn172 del and the other has a deletion of AA 462-470. Review. PMID: 20470930
    11. these data highlight the possibility of a physiological role for K6/K16 heterodimers in keratinocyte cell migration, in addition to the heterodimer's known functions in cell differentiation and mechanical resilience. PMID: 20403371
    12. The mutation of 521T--> C in the K6A gene is the causing mutation in pachyonychia congenita type I. PMID: 20140871
    13. Mutations Y465H and N171D of the KRT16A gene were detected in the sporadic pachyonychia congenita cases. PMID: 19806570
    14. Four new missense and five known mutations in K6a, one new deletion and three previously identified missense mutations in K16, plus one known mutation in K17 are reported in pachyonychia congenita. PMID: 17719747
    15. PC-1 is due to mutations of the KRT16 gene or its expression partner KRT6A, wheres PC-2 is caused by mutations in the KRT17 or KRT6B genes. PMID: 18489596
    16. Three novel and four recurrent keratin 6A (KRT6A) mutations were found in Chinese patients with pachyonychia congenita type 1 PMID: 19416275
    17. Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients. PMID: 19699613

    顯示更多

    收起更多

  • 相關疾病:
    Pachyonychia congenita 3 (PC3)
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the corneal epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 6443

    OMIM: 148041

    KEGG: hsa:3853

    STRING: 9606.ENSP00000369317

    UniGene: Hs.700779



主站蜘蛛池模板: av无码中文字幕不卡一区二区三区| 中文字幕一区二区三区日韩精品| 久久久久久欧美精品se一二三四| 亚洲国产另类久久久精品黑人| 日日av色欲香天天综合网| 果冻传媒2021精品一区| 一本无码中文字幕在线观| 少妇高潮太爽了在线视频| 无码国产精品一区二区免费式影视| 扒开双腿吃奶呻吟做受视频| 成人综合婷婷国产精品久久| 大乳丰满人妻中文字幕日本电影 | 日产精品卡1卡2卡三卡在线| 国产超级va在线观看视频| 久久久久久久久蜜桃| www国产成人免费观看视频| 欧美成va视频网站| 4hu四虎永久在线影院| 国产又粗又猛又爽又黄的视频在线观看动漫| 国产成人无码av在线播放dvd| 国产免费丝袜调教视频| 六月丁香综合在线视频| 波多野结衣一区二区免费视频| 国产性色αv视频免费| 老太脱裤让老头玩ⅹxxxx| 国产成人免费97在线| 西西人体大胆无码视频| 丰满少妇被猛烈进入试看| 乱子伦一区二区三区| 忍着娇喘人妻被中出中文字幕 | 麻豆国产丝袜白领秘书在线观看 | 国产成人午夜无码电影在线观看| 欧美亚洲国产片在线播放| 久久精品国产色蜜蜜麻豆| 日本熟日本熟妇在线视频| 体验区试看120秒啪啪免费| 精品女同一区二区| 蜜臀av色欲a片无码精品一区| 国产在线码观看清码视频| 国产人成无码视频在线1000 | 免费无遮挡禁18污污网站|