在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT6A Antibody

  • 中文名稱:
    KRT6A兔多克隆抗體
  • 貨號:
    CSB-PA012561ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KRT6A antibody at 5.06 μg/ml + Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 60 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA012561ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KRT6A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KRT6A
  • 別名:
    CK-6A antibody; CK-6D antibody; CK6A antibody; CK6C antibody; CK6D antibody; Cytokeratin-6A antibody; Cytokeratin-6D antibody; K2C6A_HUMAN antibody; K6A antibody; K6C antibody; K6D antibody; keratin 6A antibody; Keratin antibody; Keratin; type II cytoskeletal 6A antibody; Keratin-6A antibody; Krt6a antibody; KRT6C antibody; KRT6D antibody; type II cytoskeletal 6A antibody; Type-II keratin Kb6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Keratin, type II cytoskeletal 6A protein (305-564AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
  • 基因功能參考文獻:
    1. Manipulating K6a phosphorylation or ubiquitin-proteasome system (UPS) activity may provide opportunities to harness the innate immunity of epithelia against infection. PMID: 29191848
    2. Several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries. PMID: 29357356
    3. KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia. PMID: 27041546
    4. we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis. PMID: 24708461
    5. Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens. PMID: 23006328
    6. Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A need further studies to confirm the rare feature of fissured tongue PMID: 22668561
    7. We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations. PMID: 22264670
    8. Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system. PMID: 22098151
    9. This report is the first case of pachyonychia congenita with laryngeal obstruction in which the gene mutation has been established (a deletional mutation in keratin 6a). PMID: 21554383
    10. Focal palmoplantar keratoderma is associated with mutations in keratin K6c in 3 families. 2 unrelated families have Asn172 del and the other has a deletion of AA 462-470. Review. PMID: 20470930
    11. these data highlight the possibility of a physiological role for K6/K16 heterodimers in keratinocyte cell migration, in addition to the heterodimer's known functions in cell differentiation and mechanical resilience. PMID: 20403371
    12. The mutation of 521T--> C in the K6A gene is the causing mutation in pachyonychia congenita type I. PMID: 20140871
    13. Mutations Y465H and N171D of the KRT16A gene were detected in the sporadic pachyonychia congenita cases. PMID: 19806570
    14. Four new missense and five known mutations in K6a, one new deletion and three previously identified missense mutations in K16, plus one known mutation in K17 are reported in pachyonychia congenita. PMID: 17719747
    15. PC-1 is due to mutations of the KRT16 gene or its expression partner KRT6A, wheres PC-2 is caused by mutations in the KRT17 or KRT6B genes. PMID: 18489596
    16. Three novel and four recurrent keratin 6A (KRT6A) mutations were found in Chinese patients with pachyonychia congenita type 1 PMID: 19416275
    17. Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients. PMID: 19699613

    顯示更多

    收起更多

  • 相關疾病:
    Pachyonychia congenita 3 (PC3)
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    Expressed in the corneal epithelium (at protein level).
  • 數據庫鏈接:

    HGNC: 6443

    OMIM: 148041

    KEGG: hsa:3853

    STRING: 9606.ENSP00000369317

    UniGene: Hs.700779



主站蜘蛛池模板: 破了亲妺妺的处免费视频国产| 免费无遮挡很爽很污很黄的网站| 香蕉eeww99国产精选免费| 久久丫精品系列| 亚洲欧洲自拍拍偷午夜色| 特级无码毛片免费视频播放▽| 欧美日产亚洲国产精品| 在线 | 国产精品星空传媒丿| 大桥久未无码吹潮在线观看| 人人妻一区二区三区| 久久俺也去丁香综合色| 亚洲乱码一区av春药高潮| 麻豆精产国品| 国产α片免费观看在线人 | 小荡货好紧好爽奶头大视频 | 欧美国产日韩a欧美在线观看| 国产精品免费久久久久影院仙踪林| 50路60路老熟妇啪啪| 国产一区二区野外| 97无码免费人妻超级碰碰碰碰| 国产内射老熟女aaaa| 国产精品久久久久久久久人妻| 天天做天天欢摸夜夜摸狠狠摸| 国产亚洲精品久久久闺蜜| 日日碰狠狠添天天爽| 久久中文字幕人妻av熟女| 国产99视频精品免费视频6| 99re6热在线精品视频播放| 久久久久人妻精品一区蜜桃| 亚洲国产天堂久久久久久| 国产高清在线精品一区下载| 国产自偷自偷免费一区| 久久综合九色综合97网| 国产老太睡小伙子视频| 国产精品无码专区| 在线无码中文字幕一区| 成年女人片免费视频播放a| 欧美超级乱婬视频播放| 日韩人妻无码一区二区三区综合部| av激情亚洲男人的天堂| 性高湖久久久久久久久|