在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human Keratin, type II cytoskeletal 6A(KRT6A) ELISA kit

Human Keratin, type II cytoskeletal 6A(KRT6A) ELISA kit

  • 中文名稱：
    人角蛋白II型細胞骨架6A(KRT6A)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL012561HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人角蛋白II型細胞骨架6A(KRT6A)酶聯(lián)免疫試劑盒（CSB-EL012561HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的KRT6A含量。KRT6A是一個靶點，在生物體內它屬于角蛋白相關基因，角蛋白在維持細胞結構和功能方面發(fā)揮重要作用。目前研究可能聚焦于其在細胞增殖、分化等生理過程中的機制，以及其在疾病如某些皮膚病發(fā)生發(fā)展中的作用。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于基礎醫(yī)學研究中KRT6A蛋白在皮膚疾病模型、腫瘤微環(huán)境分析、細胞應激反應等場景的動態(tài)監(jiān)測，可配合基因編輯、藥物干預等實驗方案開展分子機制探索，為上皮細胞生物學研究提供可靠的定量分析工具。本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
  • 別名：
    CK-6A ELISA Kit; CK-6D ELISA Kit; CK6A ELISA Kit; CK6C ELISA Kit; CK6D ELISA Kit; Cytokeratin-6A ELISA Kit; Cytokeratin-6D ELISA Kit; K2C6A_HUMAN ELISA Kit; K6A ELISA Kit; K6C ELISA Kit; K6D ELISA Kit; keratin 6A ELISA Kit; Keratin ELISA Kit; Keratin; type II cytoskeletal 6A ELISA Kit; Keratin-6A ELISA Kit; Krt6a ELISA Kit; KRT6C ELISA Kit; KRT6D ELISA Kit; type II cytoskeletal 6A ELISA Kit; Type-II keratin Kb6 ELISA Kit
  • 縮寫：
    KRT6A
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human KRT6A in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 87
    Range % 82-91
    1:2 Average % 84
    Range % 80-88
    1:4 Average % 103
    Range % 98-108
    1:8 Average % 90
    Range % 85-94
  • 回收率：
    The recovery of human KRT6A spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 98 94-103
    EDTA plasma (n=4) 94 90-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.098 2.102 2.100 1.955
    5 1.721 1.793 1.757 1.612
    2.5 1.382 1.421 1.402 1.257
    1.25 1.090 1.150 1.120 0.975
    0.625 0.695 0.714 0.705 0.560
    0.312 0.459 0.436 0.448 0.303
    0.156 0.267 0.262 0.265 0.120
    0 0.142 0.147 0.145 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
  • 基因功能參考文獻：
    1. Manipulating K6a phosphorylation or ubiquitin-proteasome system (UPS) activity may provide opportunities to harness the innate immunity of epithelia against infection. PMID: 29191848
    2. Several missense polymorphisms in KRT6A, KRT6B and KRT6C that lead to a higher risk for dental caries. PMID: 29357356
    3. KRT6A genetic mutation is associate with the development of Pachyonychia Congenita in patients in Australia. PMID: 27041546
    4. we here describe a family with pachyonychia congenita K6a, manifesting atypical symptoms of impaired wound healing and cheilitis. PMID: 24708461
    5. Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens. PMID: 23006328
    6. Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A need further studies to confirm the rare feature of fissured tongue PMID: 22668561
    7. We observed a higher likelihood of oral leukokeratosis in individuals harboring KRT6A mutations. PMID: 22264670
    8. Phenotypic differences exist between KRT6A and KRT16 mutations support adoption of a new classification system. PMID: 22098151
    9. This report is the first case of pachyonychia congenita with laryngeal obstruction in which the gene mutation has been established (a deletional mutation in keratin 6a). PMID: 21554383
    10. Focal palmoplantar keratoderma is associated with mutations in keratin K6c in 3 families. 2 unrelated families have Asn172 del and the other has a deletion of AA 462-470. Review. PMID: 20470930
    11. these data highlight the possibility of a physiological role for K6/K16 heterodimers in keratinocyte cell migration, in addition to the heterodimer's known functions in cell differentiation and mechanical resilience. PMID: 20403371
    12. The mutation of 521T--> C in the K6A gene is the causing mutation in pachyonychia congenita type I. PMID: 20140871
    13. Mutations Y465H and N171D of the KRT16A gene were detected in the sporadic pachyonychia congenita cases. PMID: 19806570
    14. Four new missense and five known mutations in K6a, one new deletion and three previously identified missense mutations in K16, plus one known mutation in K17 are reported in pachyonychia congenita. PMID: 17719747
    15. PC-1 is due to mutations of the KRT16 gene or its expression partner KRT6A, wheres PC-2 is caused by mutations in the KRT17 or KRT6B genes. PMID: 18489596
    16. Three novel and four recurrent keratin 6A (KRT6A) mutations were found in Chinese patients with pachyonychia congenita type 1 PMID: 19416275
    17. Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients. PMID: 19699613

    顯示更多

    收起更多

  • 相關疾病：
    Pachyonychia congenita 3 (PC3)
  • 蛋白家族：
    Intermediate filament family
  • 組織特異性：
    Expressed in the corneal epithelium (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6443

    OMIM: 148041

    KEGG: hsa:3853

    STRING: 9606.ENSP00000369317

    UniGene: Hs.700779



主站蜘蛛池模板： 亚洲精品无码成人网站| 夜夜澡人摸人人添人人看| 亚洲国产精品无码久久久久高潮 | 又大又长粗又爽又黄少妇视频 | 在线播放人成视频观看| 福利视频在线播放| 国产成人一区二区三区在线| 免费无码又爽又刺激高潮的app| 国产精品丝袜亚洲熟女| 一本久久a久久精品综合| а天堂8中文最新版在线官网| 国产乱理伦片在线观看| 久久99久久99久久综合| 日韩经典精品无码一区| 久久久亚洲色| 久久99精品国产麻豆| 蜜桃视频无码区在线观看| 免费1级做爰片在线观看爱 | 国产亚洲精品福利视频| 色综合色狠狠天天综合网| 国产精品福利自产拍在线观看| 國产一二三内射在线看片| 国产av午夜精品一区二区三区| 国内精品一区二区三区不卡| 国产沙发午睡系列999| 国内精品久久久久久久久电影网| 妺妺窝人体色www聚色窝仙踪| 一区二区在线 | 欧洲| 久久精品无码av| 亚洲欧美综合精品成人网站| 99视频国产精品免费观看| 精品久久一区二区乱码| 日本高清视频网站www| 亚洲经典三级| 国产精品一品二区三区的使用体验| 无码人妻丰满熟妇区96| 免费床视频大全叫不停欧美| 国产亚洲精品自在久久vr| 久久综合色_综合色88| 日本中文字幕一区二区有码在线 | 久久久精品一区aaa片|