在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KMT5C Antibody

KMT5C Antibody

  • 中文名稱：
    KMT5C兔多克隆抗體
  • 貨號：
    CSB-PA769808LA11HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA769808LA11HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KMT5C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KMT5C
  • 別名：
    Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2), KMT5C, SUV420H2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase KMT5C protein (235-345aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KMT5C Antibody (CSB-PA769808LA11HU)，的標記方式是Non-conjugated。對于KMT5C Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA769808LB11HU KMT5C Antibody, HRP conjugated ELISA
    FITC CSB-PA769808LC11HU KMT5C Antibody, FITC conjugated
    Biotin CSB-PA769808LD11HU KMT5C Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
  • 基因功能參考文獻：
    1. The analysis of human pancreatic cancer biopsies was concordant with these findings, because high levels of SUV420H2 correlated with a loss of epithelial characteristics in progressively invasive cancer. Together, these data indicate that SUV420H2 is an upstream epigenetic regulator of epithelial/mesenchymal state control. PMID: 29229751
    2. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis. PMID: 27862226
    3. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. PMID: 28778956
    4. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1. PMID: 27105552
    5. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
    6. One of the most downregulated genes in response to SUV420H2 expression was the Src substrate, tensin-3, a focal adhesion protein that contributes to cancer cell migration. PMID: 25814362
    7. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity. PMID: 24396869
    8. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation PMID: 21206904
    9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase. PMID: 16322686
    10. The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] PMID: 18296440
    11. occurrence of an unusual TG 3' splice site in intron 5 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28405

    OMIM: 613198

    KEGG: hsa:84787

    STRING: 9606.ENSP00000255613

    UniGene: Hs.590982



主站蜘蛛池模板： 狠狠热精品免费视频| 亚洲男人的天堂www| 青椒国产97在线熟女| 日韩免费无码成人久久久久久片| 99re久久精品国产首页| 美丽的熟妇中文字幕| 美女内射毛片在线看免费人动物| 人妻夜夜爽天天爽| 中文字幕人妻a片免费看| 日本高清在线天码一区播放| 日本日本乱码伦专区| 内射老阿姨1区2区3区4区| 美女视频黄是免费| 国产精品videossex久久发布 | 黄页网站视频| 亚洲欧洲自拍拍偷精品 美利坚| 精品国产亚洲午夜精品av| 超薄肉色丝袜一区二区| 精品国产一区二区三区av性色 | yyyy11111少妇无码影院| 国产一区二区三区精品av| 国产肉丝袜视频在线观看| 人妻无码久久一区二区三区免费 | 色偷偷亚洲第一成人综合网址| 爽爽午夜影视窝窝看片| 巨大乳女人做爰视频在线看| 成人女人看片免费视频放人| 女人张开腿让男桶喷水高潮| 人妻少妇精品视频无码综合| 免费观看国产小粉嫩喷水| 亚洲跨种族黑人xxxxx| 欧美牲交40_50a欧美牲交aⅴ| 老妇肥熟凸凹丰满刺激| 欧洲熟妇色xxxxx视频| 成人国产一区二区精品小说| 久久无码人妻影院| 黑人巨茎大战欧美白妇免费| 亚洲欧美成人片在线观看| 天天爽夜夜爽人人爽免费| 色偷偷888欧美精品久久久| 亚洲va久久久噜噜噜久久4399|