在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KMT5C Antibody, FITC conjugated

KMT5C Antibody, FITC conjugated

  • 中文名稱：
    KMT5C兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA769808LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KMT5C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KMT5C
  • 別名：
    Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2), KMT5C, SUV420H2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase KMT5C protein (235-345aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
  • 基因功能參考文獻：
    1. The analysis of human pancreatic cancer biopsies was concordant with these findings, because high levels of SUV420H2 correlated with a loss of epithelial characteristics in progressively invasive cancer. Together, these data indicate that SUV420H2 is an upstream epigenetic regulator of epithelial/mesenchymal state control. PMID: 29229751
    2. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis. PMID: 27862226
    3. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. PMID: 28778956
    4. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1. PMID: 27105552
    5. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
    6. One of the most downregulated genes in response to SUV420H2 expression was the Src substrate, tensin-3, a focal adhesion protein that contributes to cancer cell migration. PMID: 25814362
    7. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity. PMID: 24396869
    8. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation PMID: 21206904
    9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase. PMID: 16322686
    10. The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] PMID: 18296440
    11. occurrence of an unusual TG 3' splice site in intron 5 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
  • 數據庫鏈接：

    HGNC: 28405

    OMIM: 613198

    KEGG: hsa:84787

    STRING: 9606.ENSP00000255613

    UniGene: Hs.590982



主站蜘蛛池模板： 亚洲桃色天堂网| 亚洲欧美韩国综合色| 欧洲亚洲国产成人综合色婷婷| 忘忧草影院在线www韩国日本| 长腿校花无力呻吟娇喘的视频 | 精品国产精品三级精品av网址| 国产精品久久久久秋霞鲁丝| 国产乱子伦一区二区三区视频播放| 久久无码av一区二区三区电影网| 秋霞在线观看秋| 久久久久99精品成人片牛牛影视| 精品av一区二区久久久| 久久国产成人精品av| 精品产区wnw2544| 国产午夜精品一区二区三区老| 亚洲日本乱码一区二区产线一∨| 日日躁夜夜躁狠狠久久av| 免费无码成人片| 欧美精品成人v高清视频| 亚洲人成无码网站在线观看| 精品一区二区三区无码免费直播| 国产99久一区二区三区a片| 2020久久国产综合精品swag| 九九综合va免费看| 无码精品人妻一区二区三区免费看| 日本一二免费不卡区| 色五月丁香五月综合五月| 虎白女粉嫩尤物福利视频| 亚洲人成人无码网www国产| 蜜芽av无码精品国产午夜| 西西人体444www高清大胆| 97免费人妻无码视频| 国内熟妇人妻色在线视频| 国产精品青草久久福利不卡| 肉岳疯狂69式激情的高潮| 国产人妻高清国产拍精品| 亚洲国产成人久久综合碰碰| 久久精品无码精品免费专区| 丰满人妻被公侵犯高清版| 热99re久久国超精品首页| 国产精品三级一区二区|