在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KMT5C Antibody, FITC conjugated

KMT5C Antibody, FITC conjugated

  • 中文名稱：
    KMT5C兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA769808LC21HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KMT5C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KMT5C
  • 別名：
    Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2), KMT5C, SUV420H2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase KMT5C protein (235-345aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
  • 基因功能參考文獻：
    1. The analysis of human pancreatic cancer biopsies was concordant with these findings, because high levels of SUV420H2 correlated with a loss of epithelial characteristics in progressively invasive cancer. Together, these data indicate that SUV420H2 is an upstream epigenetic regulator of epithelial/mesenchymal state control. PMID: 29229751
    2. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis. PMID: 27862226
    3. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. PMID: 28778956
    4. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1. PMID: 27105552
    5. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
    6. One of the most downregulated genes in response to SUV420H2 expression was the Src substrate, tensin-3, a focal adhesion protein that contributes to cancer cell migration. PMID: 25814362
    7. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity. PMID: 24396869
    8. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation PMID: 21206904
    9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase. PMID: 16322686
    10. The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] PMID: 18296440
    11. occurrence of an unusual TG 3' splice site in intron 5 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
  • 數據庫鏈接：

    HGNC: 28405

    OMIM: 613198

    KEGG: hsa:84787

    STRING: 9606.ENSP00000255613

    UniGene: Hs.590982



主站蜘蛛池模板： 久久久久久av无码免费网站下载| 国产精品久久久久久不卡盗摄 | 精品国产av一二三四区| 久久人妻无码一区二区| 四虎成人永久在线精品免费| 国精产品69永久中国有限 | 97伦伦午夜电影理伦片| 粗大挺进尤物人妻中文字幕| 国产粗话肉麻对白在线播放| 波多野成人无码精品电影| 青青草大香焦在线综合视频| 国产精品一区二区在线观看| 国语自产免费精品视频在| 欧美在线观看免费专区| 精品一区二区三区在线成人| 成年免费视频黄网站在线观看| 四川骚妇无套内射舔了更爽| 国产萌白酱喷水视频在线观看| 精品av无码国产一区二区| 国产艳妇av在线出轨| 日日碰狠狠添天天爽超碰97| 亚洲男人的天堂av手机在线观看 | 美女裸体十八禁免费网站| 亚洲精品久久久久久久久久久捆绑| 久久精品亚洲精品无码| 国模无码视频一区二区三区| 久久国产成人免费网站| 乱子伦国产对白在线播放| 色欲色香天天天综合vvv| 人妻夜夜爽天天爽三区麻豆av网站| 欧美成人看片一区二三区图文| av色综合久久天堂av色综合| 亚洲午夜国产精品无码老牛影视| 久久综合一色综合久久小蛇| 九九视频麻婆豆腐在线观看| 亚洲最大成人网站| 国产嫖妓风韵犹存对白| 亚洲一卡2卡三卡4卡国色天香| 777亚洲精品乱码久久久久久| 国产综合精品一区二区三区 | 国产精品va在线观看无码不卡|