在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KMT5C Antibody, HRP conjugated

KMT5C Antibody, HRP conjugated

  • 中文名稱：
    KMT5C兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA769808LB11HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KMT5C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KMT5C
  • 別名：
    Histone-lysine N-methyltransferase KMT5C (EC 2.1.1.43) (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2), KMT5C, SUV420H2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase KMT5C protein (235-345aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4. May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4.
  • 基因功能參考文獻：
    1. The analysis of human pancreatic cancer biopsies was concordant with these findings, because high levels of SUV420H2 correlated with a loss of epithelial characteristics in progressively invasive cancer. Together, these data indicate that SUV420H2 is an upstream epigenetic regulator of epithelial/mesenchymal state control. PMID: 29229751
    2. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis. PMID: 27862226
    3. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. PMID: 28778956
    4. The sequences surrounding both methylation sites do not fit to the specificity profile of SUV4-20H1. PMID: 27105552
    5. Upregulation of long non-coding RNA PAPAS in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2. PMID: 26904956
    6. One of the most downregulated genes in response to SUV420H2 expression was the Src substrate, tensin-3, a focal adhesion protein that contributes to cancer cell migration. PMID: 25814362
    7. The crystal structure of SUV420H2 was used to characterize substrate selectivity and product specificity. PMID: 24396869
    8. SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation PMID: 21206904
    9. The decrease in trimethylation of lysine 20 of histone H4 in breast cancer cells was accompanied by diminished expression of Suv4-20h2 histone methyltransferase. PMID: 16322686
    10. The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20] PMID: 18296440
    11. occurrence of an unusual TG 3' splice site in intron 5 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily
  • 數據庫鏈接：

    HGNC: 28405

    OMIM: 613198

    KEGG: hsa:84787

    STRING: 9606.ENSP00000255613

    UniGene: Hs.590982



主站蜘蛛池模板： 日本午夜看x费免| 久久久受www免费人成| 国产免费人成视频尤勿视频| 亚洲乱码日产精品bd在线| 亚洲欧洲日本精品专线| 亚洲色婷婷一区二区三区| 无码人妻久久一区二区三区不卡| 日韩人妻无码精品专区906188| 国色天香社区在线视频| 99久热在线精品996热是什么| 国产亚洲精久久久久久无码77777| 久久亚洲国产精品123区| 亚洲欧美国产va在线播放 | 青草内射中出高潮| 男插女高潮一区二区| 中文字幕无码av免费久久| 51国偷自产一区二区三区| 性xxxxx大片免费视频| 被技师按摩到高潮的少妇| 亚洲最大av网站在线观看| 天堂中文最新版在线官网在线 | 中文字幕人妻熟女人妻a片| 国产av偷闻女邻居内裤被发现| 放荡的少妇2欧美版| 四虎国产成人永久精品免费| 午夜福利无遮挡十八禁视频| 国产在线乱子伦一区二区| 国产精欧美一区二区三区| 人与禽性视频77777| 无码av在线一本无码| 国产成年无码久久久久毛片| 99re6在线视频精品免费| 久久久久国色av免费看图片| 国产作爱激烈叫床视频| 乱中年女人伦| 99在线精品一区二区三区| 日本三级带日本三级带黄| 欧美激情a∨在线视频播放| 蜜臀亚洲精品国产aⅴ综合第一| 人妻少妇精品视中文字幕国语| 无码熟妇人妻av在线电影|