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  4. KLHL12 Antibody

KLHL12 Antibody

  • 中文名稱：
    KLHL12兔多克隆抗體
  • 貨號：
    CSB-PA700650LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA700650LA01HU diluted at 1:800 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of PC-3 cells with CSB-PA700650LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KLHL12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KLHL12
  • 別名：
    C3IP1 antibody; CUL3 interacting protein 1 antibody; CUL3-interacting protein 1 antibody; DKIR antibody; DKIR homolog antibody; FLJ27152 antibody; hDKIR antibody; Kelch like 12 (Drosophila) antibody; Kelch like 12 antibody; Kelch like 12 variant antibody; Kelch like protein 12 antibody; Kelch like protein C3IP1 antibody; kelch-like family member 12 antibody; Kelch-like protein 12 antibody; KLH12_HUMAN antibody; KLHL 12 antibody; klhl12 antibody; OTTHUMP00000038799 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kelch-like protein 12 protein (1-220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KLHL12 Antibody (CSB-PA700650LA01HU)，的標記方式是Non-conjugated。對于KLHL12 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA700650LB01HU KLHL12 Antibody, HRP conjugated ELISA
    FITC CSB-PA700650LC01HU KLHL12 Antibody, FITC conjugated
    Biotin CSB-PA700650LD01HU KLHL12 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
  • 基因功能參考文獻：
    1. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    2. p44/42 MAPK phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor stimulation. PMID: 27155323
    3. KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues. PMID: 26717573
    4. molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR. PMID: 15383316
    5. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor PMID: 18303015

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  • 亞細胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle.
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
  • 數據庫鏈接：

    HGNC: 19360

    OMIM: 614522

    KEGG: hsa:59349

    STRING: 9606.ENSP00000356230

    UniGene: Hs.706793



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