在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KLHL12 Antibody, HRP conjugated

KLHL12 Antibody, HRP conjugated

  • 中文名稱：
    KLHL12兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA700650LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KLHL12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KLHL12
  • 別名：
    C3IP1 antibody; CUL3 interacting protein 1 antibody; CUL3-interacting protein 1 antibody; DKIR antibody; DKIR homolog antibody; FLJ27152 antibody; hDKIR antibody; Kelch like 12 (Drosophila) antibody; Kelch like 12 antibody; Kelch like 12 variant antibody; Kelch like protein 12 antibody; Kelch like protein C3IP1 antibody; kelch-like family member 12 antibody; Kelch-like protein 12 antibody; KLH12_HUMAN antibody; KLHL 12 antibody; klhl12 antibody; OTTHUMP00000038799 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kelch-like protein 12 protein (1-220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
  • 基因功能參考文獻：
    1. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    2. p44/42 MAPK phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor stimulation. PMID: 27155323
    3. KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues. PMID: 26717573
    4. molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR. PMID: 15383316
    5. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor PMID: 18303015

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle.
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
  • 數據庫鏈接：

    HGNC: 19360

    OMIM: 614522

    KEGG: hsa:59349

    STRING: 9606.ENSP00000356230

    UniGene: Hs.706793



主站蜘蛛池模板： 妺妺窝人体色www在线观看| 国产精品夜夜春夜夜爽久久| 国产精品高潮呻吟av久久男男| 亚洲男人的天堂av手机在线观看| 成人午夜视频精品一区| 久久精品无码免费不卡 | 伊人色综合网久久天天| 无码国产精品一区二区免费16| 国产98色在线 | 国产| 人妻熟女 视频二区 视频一区| 九九热久久只有精品2| 影音先锋久久久久av综合网成人| 人妻熟妇乱又伦精品视频中文字幕| 久久综合给综合给久久| 九九视频麻婆豆腐在线观看| 国产精品va无码免费| 欧美性猛交xxxx免费视频软件 | 老太脱裤子让老头玩xxxxx| 热99re久久精品国产首页免费| 婷婷丁香六月激情综合啪| 亚洲欧美日韩精品久久| 国产内射999视频一区| 免费看女人与公拘交酡过程| 欧美中日韩免费观看网站| 亚洲色偷偷色噜噜狠狠99网| 真人做受试看120分钟小视频 | 五月丁香啪啪激情综合色九色 | 久久久久99精品成人片试看| 久久精品国产99国产精品导航| 极品无码av国模在线观看| 久久国产亚洲精品无码| 最爽free性欧美人妖| 日韩 国产 变态另类 欧美| 久久久久国产精品人妻电影| 日本亚洲欧洲无免费码在线| 欧美性猛交xxxx乱大交丰满| 日产精品卡2卡三卡乱码网站| 亚洲日韩一区精品射精| 88国产精品欧美一区二区三区| 青乐娱精品视频一国产分类| 男女猛烈激情xx00免费视频|