在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KLHL12 Antibody, FITC conjugated

KLHL12 Antibody, FITC conjugated

  • 中文名稱：
    KLHL12兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA700650LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KLHL12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KLHL12
  • 別名：
    C3IP1 antibody; CUL3 interacting protein 1 antibody; CUL3-interacting protein 1 antibody; DKIR antibody; DKIR homolog antibody; FLJ27152 antibody; hDKIR antibody; Kelch like 12 (Drosophila) antibody; Kelch like 12 antibody; Kelch like 12 variant antibody; Kelch like protein 12 antibody; Kelch like protein C3IP1 antibody; kelch-like family member 12 antibody; Kelch-like protein 12 antibody; KLH12_HUMAN antibody; KLHL 12 antibody; klhl12 antibody; OTTHUMP00000038799 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Kelch-like protein 12 protein (1-220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins.
  • 基因功能參考文獻(xiàn)：
    1. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    2. p44/42 MAPK phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12, but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor stimulation. PMID: 27155323
    3. KLHL12 promotes ubiquitination of the dopamine D4 receptor on non-lysine residues. PMID: 26717573
    4. molecular cloning and characterization of a novel gene, encoded a human kelch protein containing 568 amino acid residues, termed hDKIR. PMID: 15383316
    5. KLHL12 specifically interacts with the D4 polymorphism, thereby building up a Cul3-E3 ligase complex with substrate specificity toward the D4 receptor PMID: 18303015

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, COPII-coated vesicle.
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19360

    OMIM: 614522

    KEGG: hsa:59349

    STRING: 9606.ENSP00000356230

    UniGene: Hs.706793



主站蜘蛛池模板： 欧美搡bbbbb搡bbbbb| 成人综合婷婷国产精品久久| 正在播放重口老熟女露脸| 久久青青草原国产毛片| 新普新京亚洲欧美日韩国产| 免费无码又爽又刺激成人| 国产成人综合久久免费| 777天堂麻豆爱综合视频| 中文字幕乱码中文乱码777| 欧美性黑人极品hd另类| 亚洲vs成人无码人在线观看堂| 国内精品自线一区二区三区2021| 精品国产av一区二区三区| 男阳茎进女阳道视频大全| 日本又黄又潮娇喘视频| 人成午夜免费大片| 上司人妻互换中文字幕| 欧美老肥妇做爰bbww| 9九色桋品熟女内射| 夜夜澡天天碰人人爱av| 131美女爱做视频免费| 精产国品一二三产区m553麻豆| 波多野结衣 黑人| 国产在线无码一区二区三区| 国产一区二区丝袜高跟鞋| 熟女性饥渴一区二区三区| 成人精品视频一区二区三区| 中文字幕人妻av一区二区| 亚洲人成人影院在线观看| 亚洲人妻av伦理| 亚洲国产精品特色大片观看完整版| 欧美日韩国产亚洲沙发| 日韩a人毛片精品无人区乱码| 亚洲欧美日韩综合久久久久久| 国产成人久久婷婷精品流白浆| 天天躁日日躁狠狠躁超碰97| 天堂а√在线最新版中文| 四库影院永久四虎精品国产| 香蕉av777xxx色综合一区| 国产精品久久久久蜜臀| 国产精品高潮呻吟av久久|