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  4. KCTD6 Antibody, HRP conjugated

KCTD6 Antibody, HRP conjugated

  • 中文名稱(chēng)：
    KCTD6兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA822756LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) KCTD6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCTD6
  • 別名：
    BTB/POZ domain-containing protein KCTD6 antibody; KCASH3 antibody; kctd6 antibody; KCTD6_HUMAN antibody; MGC27385 antibody; potassium channel tetramerization domain containing 6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
  • 基因功能參考文獻(xiàn)：
    1. A biophysical characterization of the POZ/BTB of KCTD6, is reported. PMID: 24307990
    2. Rescuing KCASHs expression reduces the Hedgehog-dependent medulloblastoma growth, suggesting that loss of members of this novel family of native HDAC inhibitors is crucial in sustaining Hh pathway-mediated tumorigenesis. PMID: 21472142
  • 亞細(xì)胞定位：
    Cytoplasm, myofibril, sarcomere, M line.
  • 組織特異性：
    Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 22235

    KEGG: hsa:200845

    STRING: 9606.ENSP00000347188

    UniGene: Hs.13982



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