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  4. KCNAB1 Antibody, Biotin conjugated

KCNAB1 Antibody, Biotin conjugated

  • 中文名稱：
    KCNAB1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA012013LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KCNAB1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNAB1
  • 別名：
    hKvb3 antibody; hKvBeta3 antibody; K(+) channel subunit beta-1 antibody; KCAB1_HUMAN antibody; KCNA1B antibody; KCNAB1 antibody; Kv-beta-1 antibody; Kvb1.3 antibody; Voltage-gated potassium channel beta-1 subunit antibody; Voltage-gated potassium channel subunit beta-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Voltage-gated potassium channel subunit beta-1 protein (287-401AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the closure of KCNA1, KCNA2 and KCNA5 channels. Accelerates KCNA4 channel closure. Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4. Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6. Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1. Enhances KCNB1 and KCNB2 channel activity. Binds NADPH; this is required for efficient down-regulation of potassium channel activity. Has NADPH-dependent aldoketoreductase activity. Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity.
  • 基因功能參考文獻：
    1. Genetic variations of KCNAB1 and CRYAA are associated with age-related nuclear cataract. PMID: 24951543
    2. Protein kinase C inhibition results in a Kv 1.5 and Kv beta 1.3 pharmacology closer to Kv 1.5 channels PMID: 24946104
    3. These results support KCNAB1 as a susceptibility gene for lateral temporal epilepsy , in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy. PMID: 21333500
    4. Double-mutant cycle analysis indicates that R5 of Kvbeta1.3 interacts with A501 and T480 of Kv1.5, residues located deep within the pore of the channel. PMID: 18987637
  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Shaker potassium channel beta subunit family
  • 組織特異性：
    In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left
  • 數據庫鏈接：

    HGNC: 6228

    OMIM: 601141

    KEGG: hsa:7881

    STRING: 9606.ENSP00000419952

    UniGene: Hs.654519



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