在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL17C Antibody

  • 中文名稱:
    IL17C兔多克隆抗體
  • 貨號:
    CSB-PA301181
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CX2 antibody; Cytokine CX2 antibody; IL 17C antibody; IL 21 antibody; IL-17C antibody; IL17C antibody; IL17C_HUMAN antibody; Interleukin 17C antibody; Interleukin-17C antibody; MGC126884 antibody; MGC138401 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide from Human protein at AA range: 81-130
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
  • 基因功能參考文獻:
    1. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
    2. Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID: 28739826
    3. Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID: 28346430
    4. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    5. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID: 25012243
    6. IL-17C is an essential epithelial cell-derived cytokine. PMID: 23944933
    7. Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID: 23892590
    8. Interleukin-17C is present in the tissue around aseptic loosened implants. PMID: 23474800
    9. IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID: 23221046
    10. Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID: 22994872
    11. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID: 23359500
    12. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
    13. IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID: 21993848
    14. activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID: 21628458
    15. expressed in multiple sclerosis brain lesions PMID: 11984595

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-17 family
  • 數據庫鏈接:

    HGNC: 5983

    OMIM: 604628

    KEGG: hsa:27189

    STRING: 9606.ENSP00000244241

    UniGene: Hs.278911



主站蜘蛛池模板: 精品一区二区三区无码视频| 7777色鬼xxxx欧美色妇| 午夜福利无码不卡在线观看| 99精品人妻无码专区在线视频区| 国产艳妇av在线出轨| 亚洲国产超清无码专区| 狠狠色狠狠色综合日日五| 人妻丰满熟妇aⅴ无码| 狠狠做深爱婷婷久久综合一区| 欧美性开放情侣网站| 成人无码精品一区二区三区| 图片区小说区另类春色| 97久久综合亚洲色hezyo| 青青国产线免观| 欧美一道本一区二区三区| 老湿机香蕉久久久久久| 色窝窝无码一区二区三区色欲| 中文字幕日本人妻久久久免费| 亚洲国产精品一区二区第四页| 女人夜夜春高潮爽a∨片| 蜜臀av免费一区二区三区| 性人久久久久| 亚洲精品久久片久久久久| 波多野成人无码精品电影| 国产精欧美一区二区三区| 无码国产69精品久久久久同性| 美女粉嫩饱满的一线天mp4| 久久大香国产成人av| 国产精品久久..4399| 五月丁香六月激情综合在线视频| 国产成人理论无码电影网| 欧美午夜精品一区二区蜜桃 | 久久久久国产精品嫩草影院| 岛国片人妻三上悠亚| 97人人添人澡人人爽超碰| 国产乱子伦精品无码码专区| 精品夜夜爽欧美毛片视频| 九九热线精品视频16| 国产一卡2卡3卡四卡精品app| 亚洲春色在线视频| 欧美极品少妇性运交|