在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL17C Antibody

  • 中文名稱:
    IL17C兔多克隆抗體
  • 貨號:
    CSB-PA301181
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CX2 antibody; Cytokine CX2 antibody; IL 17C antibody; IL 21 antibody; IL-17C antibody; IL17C antibody; IL17C_HUMAN antibody; Interleukin 17C antibody; Interleukin-17C antibody; MGC126884 antibody; MGC138401 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide from Human protein at AA range: 81-130
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
  • 基因功能參考文獻:
    1. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
    2. Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID: 28739826
    3. Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID: 28346430
    4. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    5. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID: 25012243
    6. IL-17C is an essential epithelial cell-derived cytokine. PMID: 23944933
    7. Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID: 23892590
    8. Interleukin-17C is present in the tissue around aseptic loosened implants. PMID: 23474800
    9. IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID: 23221046
    10. Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID: 22994872
    11. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID: 23359500
    12. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
    13. IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID: 21993848
    14. activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID: 21628458
    15. expressed in multiple sclerosis brain lesions PMID: 11984595

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-17 family
  • 數據庫鏈接:

    HGNC: 5983

    OMIM: 604628

    KEGG: hsa:27189

    STRING: 9606.ENSP00000244241

    UniGene: Hs.278911



主站蜘蛛池模板: 国产成人影院一区二区三区| 久9re热视频这里只有精品 | 国产亚洲成av片在线观看| 蜜桃av色偷偷av老熟女| 国产手机在线亚洲精品观看 | 午夜dj高清免费观看视频| 欧美肥臀大屁股magnet| 亚洲欧美成人一区二区在线电影| 五月婷婷开心中文字幕| 无码专区3d动漫精品免费| 人妻无码一区二区三区tv| 久久国产色欲av38| 国产精品一区二区 尿失禁| 情人伊人久久综合亚洲| 国产尤物av尤物在线看| 少妇饥渴偷公乱av在线观看涩爱| 在线播放免费播放av片| 欧美人妻精品一区二区三区| 国产精品爆乳在线播放第一人称 | 久久综合国产乱子伦精品免费| 国产精品久久久久久久久久红粉| 国精品人妻无码一区二区三区喝尿| 掀开奶罩边吃边摸下娇喘视频| 少妇被粗大的猛烈进出动视频| 亚洲精品一区二区三区中文字幕| 免费国产黄网站在线观看动图| 骚女人干起来舒服视频在线| 国内精品伊人久久久久妇| 性欧美vr高清极品| 无码少妇一区二区三区芒果| 人人爽久久久噜人人看| 少妇人妻偷人激情视频| 国产真人做爰毛片视频直播| 久久精品第一国产久精国产宅男66| 性中国妓女毛茸茸视频| 国产午夜精品久久久久免费视| 久久精品亚洲日本波多野结衣| 欧洲熟妇色xxxxx视频| 国产亚洲精品久久久闺蜜| 熟女内射v888av| 国产大屁股视频免费区|