在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL17C Antibody

IL17C Antibody

  • 中文名稱：
    IL17C兔多克隆抗體
  • 貨號：
    CSB-PA809269
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA809269(IL17C Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA809269(IL17C Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cells, K562 cells, Raji cells, human fetal intestine tissue, Primary antibody: CSB-PA809269(IL17C Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CX2 antibody; Cytokine CX2 antibody; IL 17C antibody; IL 21 antibody; IL-17C antibody; IL17C antibody; IL17C_HUMAN antibody; Interleukin 17C antibody; Interleukin-17C antibody; MGC126884 antibody; MGC138401 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human IL17C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
  • 基因功能參考文獻：
    1. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
    2. Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID: 28739826
    3. Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID: 28346430
    4. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    5. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID: 25012243
    6. IL-17C is an essential epithelial cell-derived cytokine. PMID: 23944933
    7. Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID: 23892590
    8. Interleukin-17C is present in the tissue around aseptic loosened implants. PMID: 23474800
    9. IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID: 23221046
    10. Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID: 22994872
    11. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID: 23359500
    12. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
    13. IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID: 21993848
    14. activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID: 21628458
    15. expressed in multiple sclerosis brain lesions PMID: 11984595

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 數據庫鏈接：

    HGNC: 5983

    OMIM: 604628

    KEGG: hsa:27189

    STRING: 9606.ENSP00000244241

    UniGene: Hs.278911



主站蜘蛛池模板： 国产一区二区三区乱码| 蜜臀av夜夜澡人人爽人人| 少妇一边呻吟一边说使劲视频 | 久久不见久久见免费影院国语| 午夜dv内射一区二区| 亚洲综合图色40p| 无码专区aaaaaa免费视频| 日本一区二区三区免费视频| 水蜜桃精品一二三| 中文字幕无码日韩欧免费软件| 天堂√最新版中文在线天堂| 人妻aⅴ中文字幕无码| 精品国模一区二区三区| 国产卡一卡二卡三无线乱码新区| 欧美老肥妇做爰bbww| 色先锋资源久久综合5566| 久久久久国产精品人妻aⅴ牛牛| 国产精品麻豆aⅴ人妻| 成人无码亚洲精品无码| 天天天天躁天天爱天天碰2018| 欧美一区二区三区久久综合| 野花社区在线www日本| 97精品国产久热在线观看| 五月天天天综合精品无码| 欧美丰满熟妇xxxx性ppx人交| 18禁裸体女免费观看| 宅男666在线永久免费观看| 日本少妇无码精品12p| 少妇高潮喷水正在播放| 久久国语露脸国产精品电影| 亚洲精品综合五月久久小说| 奇米四色7777中文字幕| 2021亚洲国产成a在线| 好吊妞视频这里有精品| 国产亚洲无线码一区二区| 欧美婷婷丁香五月社区| 东京热无码国产精品| 国产精品久久久| 久久综合丝袜日本网| 欧洲熟妇色xxxxx欧美| 国产精品无码久久久久久|