在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL17C Antibody

IL17C Antibody

  • 中文名稱：
    IL17C兔多克隆抗體
  • 貨號：
    CSB-PA959846
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA959846(IL17C Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cells, K562 cells, Raji cells, human fetal intestine tissue, Primary antibody: CSB-PA959846(IL17C Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CX2 antibody; Cytokine CX2 antibody; IL 17C antibody; IL 21 antibody; IL-17C antibody; IL17C antibody; IL17C_HUMAN antibody; Interleukin 17C antibody; Interleukin-17C antibody; MGC126884 antibody; MGC138401 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human IL17C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
  • 基因功能參考文獻(xiàn)：
    1. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
    2. Helicobacter pylori infection was associated with a significant increase in IL-17C expression in gastric mucosa. The role of IL-17C in the pathogenesis of H. pylori-induced diseases remains to be determined. PMID: 28739826
    3. Data indicate that epithelial IL-17C promotes neutrophilic inflammation in the tumor microenvironment and suggest that IL-17C links a pathologic microbiota, as present in COPD patients, with enhanced tumor growth. PMID: 28346430
    4. CpG methylation is reduced in gingival biopsies of patients with periodontitis PMID: 26472015
    5. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer PMID: 25012243
    6. IL-17C is an essential epithelial cell-derived cytokine. PMID: 23944933
    7. Our study provides evidence that Staphylococcus aureus activates NOD2 in keratinocytes, resulting in an increased expression of IL-17C, a mechanism that may be dysregulated in atopic dermatitis. PMID: 23892590
    8. Interleukin-17C is present in the tissue around aseptic loosened implants. PMID: 23474800
    9. IL-17C is involved in the innate immune response of respiratory epithelial cells and is suppressed by cigarette smoke. PMID: 23221046
    10. Data suggest that activation of TLR5 upregulates IL17C expression in cells from intestinal mucosa and colonic adenocarcinoma; IL17C expression is upregulated in intestinal mucosa cells from patients with ulcerative colitis compared with normal cells. PMID: 22994872
    11. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. PMID: 23359500
    12. In our pilot study, we discovered significant changes in methylation patterns of genes IL-7, IL-13, IL-17C and TYK2 between henodialysis patients and healthy subjects PMID: 22506826
    13. IL-17C is an essential autocrine cytokine that regulates innate epithelial immune responses. PMID: 21993848
    14. activation of NF-kappaB (p65/p50) is crucial for the TNFalpha-induced stimulation of IL-17C expression in human keratinocytes PMID: 21628458
    15. expressed in multiple sclerosis brain lesions PMID: 11984595

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5983

    OMIM: 604628

    KEGG: hsa:27189

    STRING: 9606.ENSP00000244241

    UniGene: Hs.278911



主站蜘蛛池模板： 日本人妻中文字幕乱码系列| 国产精品嫩草影院av| 色爱情人网站| a狠狠久久蜜臀婷色中文网| 337p日本欧洲亚洲大胆精筑| 又大又硬又爽免费视频| 无码一区二区波多野结衣播放搜索| 无码专区亚洲综合另类| 欧美亚洲另类自拍丝袜| 国产精品久久久福利| 小雪尝禁果又粗又大的视频| 久久无码中文字幕无码| 国产精品亚洲一区二区z| 久久国产福利国产秒拍| 国产真实乱人偷精品视频| 色欲天天天综合网| 国产精品一区二区 尿失禁| 成人综合伊人五月婷久久| 99er国产这里只有精品视频免费| 印度妓女野外xxww| 97人妻熟女成人免费视频色戒| 日日澡夜夜澡人人高潮| 色欲天天婬色婬香综合网完整| 欧美丰满熟妇xxxx性ppx人| 公么大龟弄得我好舒服秀婷视频| 日韩精品毛片无码一区到三区| 天堂在/线中文在线资源8 | 初尝黑人嗷嗷叫中文字幕| 十八18禁国产精品www| 成人看的污污超级黄网站免费| 手机在线亚洲国产精品| 人人澡人人妻人人爽人人蜜桃| 成人性生交大片免费看96| 日本欧美一区二区三区在线播放| 亚洲伊人成综合网2222| 特级毛片爽www免费版| 永久黄网站色视频免费无下载 | 日韩欧美在线综合网另类| 在线 | 一区二区三区| 久久国产色欲av38| 任你躁在线精品免费|