在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IKZF3 Antibody

  • 中文名稱:
    IKZF3兔多克隆抗體
  • 貨號(hào):
    CSB-PA577111
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA577111(IKZF3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA577111(IKZF3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AIO antibody; Aiolos antibody; IKAROS family zinc finger 3 (Aiolos) antibody; IKAROS family zinc finger 3 antibody; Ikaros family zinc finger protein 3 antibody; IKZF 3 antibody; IKZF3 antibody; IKZF3_HUMAN antibody; zinc finger DNA binding protein Aiolos antibody; Zinc finger protein Aiolos antibody; Zinc finger protein subfamily 1A 3 (Aiolos) antibody; Zinc finger protein subfamily 1A 3 antibody; Zinc finger protein subfamily 1A; member 3 antibody; ZNFN1A3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human IKZF3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
  • 基因功能參考文獻(xiàn):
    1. The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients. PMID: 29510406
    2. Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression. PMID: 26823144
    3. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants. PMID: 27080863
    4. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA PMID: 26546109
    5. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes. PMID: 25608224
    6. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis. PMID: 25006012
    7. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB activity. PMID: 25524659
    8. identified a unique case of adult acute B-cell lymphoblastic leukemia with masked low hypodiploidy (mLH) by genomic duplication PMID: 26185311
    9. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis. PMID: 25620289
    10. A strong association between rs907091 in the IKZF3 gene and SLE was identified. PMID: 25271777
    11. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. PMID: 25446972
    12. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population. PMID: 24406073
    13. Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro. PMID: 24399134
    14. Aiolos reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo. PMID: 24823637
    15. Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559). PMID: 22626592
    16. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian). PMID: 22464253
    17. To determine the consequences of Aiolos deregulation in B-CLL, we analyzed the effects of Aiolos overexpression or down-regulation on apoptosis. PMID: 21139082
    18. distribution of positive and negative expression of Aiolos and Helios found in various types of leukemias could implicate common pathways of their regulation PMID: 20432734
    19. Aiolos knockout mice develop the symptoms of human systemic lupus erythematosus (SLE). This finding implicates Aiolos as a possible candidate gene for SLE. PMID: 12574333
    20. we show for the first time the differential Aiolos expression at the RNA and protein level in hematopoietic cell subpopulations. PMID: 19540588
    21. Short isoforms of Aiolos were detected at low levels in bone marrow of normal volunters, but were not overexpressed in a patient with acute T-cell leukemia. Data for unaltered Aiolos indicates tumor suppressor function. PMID: 11937265
    22. impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro PMID: 17296582
    23. this work demonstrates that the cellular activities of Aiolos isoforms are dependent on combinations of various functional domains arising from the differential splicing of mRNA transcripts PMID: 17646674
    24. up-regulation of Aiolos, confirmed at protein level, seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation PMID: 18184862
    25. DNA methylation directs Aiolos silencing and chromatin status in tumor cell lines, while in primary cells is mainly regulated by histone modifications. PMID: 18206652

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Ikaros C2H2-type zinc-finger protein family
  • 組織特異性:
    Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 13178

    OMIM: 606221

    KEGG: hsa:22806

    STRING: 9606.ENSP00000344544

    UniGene: Hs.371680



主站蜘蛛池模板: 男女性杂交内射妇女bbwxz| 爱情岛论坛网亚洲品质| 国产精欧美一区二区三区| 各处沟厕大尺度偷拍女厕嘘嘘| 久久精品国产首页027007| 亚洲无线码一区二区三区| 2019日韩中文字幕mv| 色综合久久无码中文字幕| 色婷婷国产精品高潮呻吟av久久| 国产 成人 综合 亚洲 网站| 粗大黑人巨精大战欧美成人| 在线播放五十路熟妇| 亚洲日韩欧洲无码av夜夜摸| 人妻少妇久久精品电影| 99久久99久久久精品齐齐| 国产97色在线 | 日韩| 亚洲热无码av一区二区东京热av| 亚洲精品国产一二三无码av| 男人添女人囗交做爰视频| 无遮挡国产高潮视频免费观看| 色多多成视频人在线观看| 免费网站内射红桃视频| 黑人巨大精品欧美| 男人扒开女人双腿猛进视频| 亚洲欧美日韩中文二区| 欧美人与zoxxxx另类| 中文字幕一区二区人妻| 国产片精品av在线观看夜色 | 人人妻人人澡人人爽偷拍台湾| 蜜臀av免费一区二区三区| 精品人妻少妇一区二区三区在线| 久青草影院在线观看国产| 亚洲人成无码网站在线观看| 九九久久精品无码专区| 欧美亚洲日韩国产网站| 国产成年码av片在线观看| 日本护士毛茸茸| 成人麻豆日韩在无码视频| 亚洲卡一卡二卡三新区乱码| 亚洲毛片αv无线播放一区| 欧美私人情侣网站|