在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IKZF3 Antibody

  • 中文名稱:
    IKZF3兔多克隆抗體
  • 貨號:
    CSB-PA003007
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using Ikaros 3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AIO antibody; Aiolos antibody; IKAROS family zinc finger 3 (Aiolos) antibody; IKAROS family zinc finger 3 antibody; Ikaros family zinc finger protein 3 antibody; IKZF 3 antibody; IKZF3 antibody; IKZF3_HUMAN antibody; zinc finger DNA binding protein Aiolos antibody; Zinc finger protein Aiolos antibody; Zinc finger protein subfamily 1A 3 (Aiolos) antibody; Zinc finger protein subfamily 1A 3 antibody; Zinc finger protein subfamily 1A; member 3 antibody; ZNFN1A3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Ikaros 3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
  • 基因功能參考文獻:
    1. The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients. PMID: 29510406
    2. Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression. PMID: 26823144
    3. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants. PMID: 27080863
    4. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA PMID: 26546109
    5. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes. PMID: 25608224
    6. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis. PMID: 25006012
    7. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB activity. PMID: 25524659
    8. identified a unique case of adult acute B-cell lymphoblastic leukemia with masked low hypodiploidy (mLH) by genomic duplication PMID: 26185311
    9. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis. PMID: 25620289
    10. A strong association between rs907091 in the IKZF3 gene and SLE was identified. PMID: 25271777
    11. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. PMID: 25446972
    12. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population. PMID: 24406073
    13. Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro. PMID: 24399134
    14. Aiolos reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo. PMID: 24823637
    15. Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559). PMID: 22626592
    16. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian). PMID: 22464253
    17. To determine the consequences of Aiolos deregulation in B-CLL, we analyzed the effects of Aiolos overexpression or down-regulation on apoptosis. PMID: 21139082
    18. distribution of positive and negative expression of Aiolos and Helios found in various types of leukemias could implicate common pathways of their regulation PMID: 20432734
    19. Aiolos knockout mice develop the symptoms of human systemic lupus erythematosus (SLE). This finding implicates Aiolos as a possible candidate gene for SLE. PMID: 12574333
    20. we show for the first time the differential Aiolos expression at the RNA and protein level in hematopoietic cell subpopulations. PMID: 19540588
    21. Short isoforms of Aiolos were detected at low levels in bone marrow of normal volunters, but were not overexpressed in a patient with acute T-cell leukemia. Data for unaltered Aiolos indicates tumor suppressor function. PMID: 11937265
    22. impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro PMID: 17296582
    23. this work demonstrates that the cellular activities of Aiolos isoforms are dependent on combinations of various functional domains arising from the differential splicing of mRNA transcripts PMID: 17646674
    24. up-regulation of Aiolos, confirmed at protein level, seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation PMID: 18184862
    25. DNA methylation directs Aiolos silencing and chromatin status in tumor cell lines, while in primary cells is mainly regulated by histone modifications. PMID: 18206652

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Ikaros C2H2-type zinc-finger protein family
  • 組織特異性:
    Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
  • 數據庫鏈接:

    HGNC: 13178

    OMIM: 606221

    KEGG: hsa:22806

    STRING: 9606.ENSP00000344544

    UniGene: Hs.371680



主站蜘蛛池模板: 亚洲熟妇无码八v在线播放| 99草草国产熟女视频在线| 熟女少妇在线视频播放| 国产亚洲福利在线视频| 日本一卡2卡3卡4卡免费乱码网站 日本无遮挡吸乳呻吟视频 | 欧性猛交ⅹxxx乱大交| 国产白嫩护士在线播放| 国产欧美国日产高清| 久久综合香蕉国产蜜臀av | 国产一卡2卡3卡四卡精品国色无边| 真实国产熟睡乱子伦视频| 国产人妻精品久久久久野外| 国产喷水福利在线视频| 成人性欧美丨区二区三区| 午夜少妇性影院私人影院在线| 51精品国产人成在线观看| 无码人妻精品一区二区三区东京热| 久久精品亚洲国产av老鸭网| 国产一区二区三区不卡在线看| 亚洲综合另类小说色区一| 熟妇人妻久久中文字幕| 亚洲国产欧美国产综合久久| 2021久久最新国产精品| 亚洲精品色午夜无码专区日韩| 国产精品久久久久av| 无码国产片观看| 国产精品高清网站| 两个人看的www在线观看| 新区乱码无人区二精东| 国产午夜无码片在线观看| 综合网日日天干夜夜久久| 国产色视频自在线观看| 免费国产午夜视频在线观看| 在线观看成人无码中文av天堂| 日韩va中文字幕无码电影 | 精品熟人妻一区二区三区四区不卡| 成 人 综合 亚洲另类| 天天爽夜夜爽人人爽88| 天天做天天摸天天爽天天爱| 高清粉嫩无套内谢国语播放| 久久超碰极品视觉盛宴|