在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human Zinc finger protein Aiolos(IKZF3) ELISA kit

Human Zinc finger protein Aiolos(IKZF3) ELISA kit

  • 中文名稱：
    人鋅指蛋白Aiolos(IKZF3)酶聯免疫試劑盒
  • 貨號：
    CSB-EL011577HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人鋅指蛋白Aiolos(IKZF3)酶聯免疫試劑盒（CSB-EL011577HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的IKZF3含量。IKZF3 是重要靶點，它屬于 IKAROS 轉錄因子家族。在正常生理中對淋巴細胞發育有調控作用。研究發現其異常表達與多種血液系統惡性腫瘤相關，如多發性骨髓瘤等，機制可能涉及對腫瘤細胞增殖、存活、凋亡等過程的影響。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，本試劑盒采用高特異性配對抗體，可精準捕獲目標蛋白，適用于科研領域對免疫調控機制、腫瘤微環境研究及藥物干預效果評估等方向，為探索IKZF3在免疫應答、腫瘤免疫逃逸中的分子機制提供可靠工具。實驗操作全程可在常規實驗室條件下完成，兼容96孔板檢測系統，支持批量樣本分析，滿足基礎研究與轉化醫學中對生物標志物定量檢測的需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    AIO ELISA Kit; Aiolos ELISA Kit; IKAROS family zinc finger 3 (Aiolos) ELISA Kit; IKAROS family zinc finger 3 ELISA Kit; Ikaros family zinc finger protein 3 ELISA Kit; IKZF 3 ELISA Kit; IKZF3 ELISA Kit; IKZF3_HUMAN ELISA Kit; zinc finger DNA binding protein Aiolos ELISA Kit; Zinc finger protein Aiolos ELISA Kit; Zinc finger protein subfamily 1A 3 (Aiolos) ELISA Kit; Zinc finger protein subfamily 1A 3 ELISA Kit; Zinc finger protein subfamily 1A; member 3 ELISA Kit; ZNFN1A3 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IKZF3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %86
    Range %80-91
    1:2Average %96
    Range %91-104
    1:4Average %96
    Range %92-109
    1:8Average %94
    Range %86-97
  • 回收率：
    The recovery of human IKZF3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-97
    EDTA plasma (n=4)9690-99
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    16002.098 1.986 2.042 1.950
    8001.357 1.298 1.328 1.236
    4000.825 0.789 0.807 0.715
    2000.500 0.481 0.491 0.399
    1000.360 0.351 0.356 0.264
    500.245 0.240 0.243 0.151
    250.156 0.152 0.154 0.062
    00.092 0.091 0.092 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
  • 基因功能參考文獻：
    1. The minor alleles of rs2941522, rs907091, rs1453559, rs12150079 and rs2872507 were statistically associated with an increased risk in Graves' disease patients. PMID: 29510406
    2. Aiolos promotes the binding of Blimp-1 to target genes and thereby enhances Blimp-1-dependent transcriptional repression. PMID: 26823144
    3. Our data indicate a possible regulatory role for the multiple sclerosis-associated IKZF3 and IQGAP1 variants. PMID: 27080863
    4. results indicate that overexpression of Aiolos may contribute to pathogenesis of SLE and RA PMID: 26546109
    5. Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes. PMID: 25608224
    6. NFKB1, CD27, LAG3 and IKZF3 are new susceptibility genes for psoriasis. PMID: 25006012
    7. lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB activity. PMID: 25524659
    8. identified a unique case of adult acute B-cell lymphoblastic leukemia with masked low hypodiploidy (mLH) by genomic duplication PMID: 26185311
    9. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis. PMID: 25620289
    10. A strong association between rs907091 in the IKZF3 gene and SLE was identified. PMID: 25271777
    11. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. PMID: 25446972
    12. A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population. PMID: 24406073
    13. Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro. PMID: 24399134
    14. Aiolos reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo. PMID: 24823637
    15. Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559). PMID: 22626592
    16. Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian). PMID: 22464253
    17. To determine the consequences of Aiolos deregulation in B-CLL, we analyzed the effects of Aiolos overexpression or down-regulation on apoptosis. PMID: 21139082
    18. distribution of positive and negative expression of Aiolos and Helios found in various types of leukemias could implicate common pathways of their regulation PMID: 20432734
    19. Aiolos knockout mice develop the symptoms of human systemic lupus erythematosus (SLE). This finding implicates Aiolos as a possible candidate gene for SLE. PMID: 12574333
    20. we show for the first time the differential Aiolos expression at the RNA and protein level in hematopoietic cell subpopulations. PMID: 19540588
    21. Short isoforms of Aiolos were detected at low levels in bone marrow of normal volunters, but were not overexpressed in a patient with acute T-cell leukemia. Data for unaltered Aiolos indicates tumor suppressor function. PMID: 11937265
    22. impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro PMID: 17296582
    23. this work demonstrates that the cellular activities of Aiolos isoforms are dependent on combinations of various functional domains arising from the differential splicing of mRNA transcripts PMID: 17646674
    24. up-regulation of Aiolos, confirmed at protein level, seems independent of Aiolos promoter H3K9 acetylation and H3K4 trimethylation PMID: 18184862
    25. DNA methylation directs Aiolos silencing and chromatin status in tumor cell lines, while in primary cells is mainly regulated by histone modifications. PMID: 18206652

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Ikaros C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
  • 數據庫鏈接：

    HGNC: 13178

    OMIM: 606221

    KEGG: hsa:22806

    STRING: 9606.ENSP00000344544

    UniGene: Hs.371680



主站蜘蛛池模板： 久久久久久午夜成人影院| 欧美成人性做爰77777| 天天躁人人躁人人躁狂躁| 国产精品美女一区二区三区| 少妇性俱乐部纵欲狂欢电影| 伊人久久丁香色婷婷啪啪| 最新 国产 精品 精品 视频| 在线成人精品国产区免费| 波多野结衣一区二区三区高清av| 激情综合亚洲色婷婷五月| 久久亚洲精品无码av红樱桃| 日韩a∨精品日韩在线观看| 国产又大又粗又爽的毛片| 99热亚洲色精品国产88| 国产办公室秘书无码精品99 | 五十路熟妇亲子交尾| 亚洲性色av性色在线观看| 亚洲欧洲日产国无高清码图片| 亚洲国产成人乱码| 国产精品久久自在自线青柠| 国产饥渴孕妇在线播放| 国产偷窥熟女高潮精品视频| 999久久久国产精品消防器材| 2020最新国产在线不卡a| 国产一区视频一区欧美| 插我一区二区在线观看| 久久er99热精品一区二区| 国产av精品一区二区三区小说| 日本国产制服丝袜一区| 非洲人与性动交ccoo| 欧美成人精精品一区二区| 中文字幕人妻第一区| 国产午夜亚洲精品不卡下载| 亚洲乱码无码永久不卡在线| 超清制服丝袜无码av福利网| 国产成人8x视频网站入口| 成年女人色毛片| 奇米在线7777在线精品| 国产国拍精品av在线观看按摩| 亚洲一区二区三区高清av| 香蕉蕉亚亚洲aav综合|