在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ICAM2 Antibody

  • 中文名稱:
    ICAM2兔多克隆抗體
  • 貨號:
    CSB-PA010950GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human ICAM2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
  • 基因功能參考文獻:
    1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. PMID: 29671117
    2. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway. PMID: 27556181
    3. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses PMID: 27592383
    4. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls. PMID: 26641849
    5. Soluble ICAM2 was higher in ADHD patients than in controls. PMID: 26377944
    6. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
    7. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus PMID: 24474251
    8. ICAM-2 was significantly more pronounced in plasma cell mastitis than in nonpathologic breast tissue. However, no significant differences in ICAM-2 immunoreactivity were detected between ductal epithelium of PCM and non-PCM. PMID: 24457076
    9. Reduced glycosylation of ICAM-2 significantly attenuated, but did not abolish, its ability to suppress metastatic properties of neuroblastoma cells. PMID: 23714211
    10. These findings suggested that the downregulated miR-125b expression was associated with proliferation and radioresistance mechanisms, probably through ICAM2 signalling. PMID: 23591197
    11. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
    12. Although ICAM-2 colocalizes with moesin and F-actin in microvilli of unstimulated endothelial cells, it is not involved in RhoA activation or cause stress fiber formation upon cross-linking. PMID: 12097408
    13. soluble DC-SIGN bound to gp120-Fc more than 100- and 50-fold better than ICAM-2-Fc and ICAM-3-Fc, respectively. Binding sites are described. PMID: 14970226
    14. The role of ICAM-2 has its recognition as potential therapeutic targets in human diseases. PMID: 15548573
    15. persistently elevated, serum levels of ICAM-2 throughout the various phases and types of Hemorrhagic fever with renal syndrome (HFRS) may be associated with the hyperfunctioning of the cellular immune response. PMID: 16987074
    16. pig and human ICAM-2 promoters exhibit many similarities PMID: 17059578
    17. The binding partner of DC-SIGN on endothelial cells is the glycan epitope Lewis(Y) (Le(Y)), expressed on ICAM-2. PMID: 18155766
    18. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. PMID: 18768213
    19. ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, microvillus.
  • 蛋白家族:
    Immunoglobulin superfamily, ICAM family
  • 數據庫鏈接:

    HGNC: 5345

    OMIM: 146630

    KEGG: hsa:3384

    STRING: 9606.ENSP00000388666

    UniGene: Hs.431460



主站蜘蛛池模板: 国产精品自在拍首页视频8| 永久黄网站免费视频性色| 国内永久福利在线视频图片| 国产男女免费完整视频网页| 无码国产精品一区二区免费模式| 女人和拘做爰正片视频| 肉感饱满中年熟妇日本| 精品人妻伦一二三区久久aaa片| 国产偷v国产偷v亚洲高清| 亚洲国产成人一区二区在线| 四虎影视88aa久久人妻| 亚洲精品无码专区在线| 亚洲综合av一区二区三区| 午夜精品久久久久久久爽| 特黄做受又大又粗又长大片 | 精品无码成人网站久久久久久 | 老熟女五十路乱子交尾中出一区| 中文字幕一区二区人妻电影| 亚色九九九全国免费视频| 中文字幕资源网| 亚洲综合av永久无码精品一区二区 | 精产国品一二三产品麻豆| 国产人妻久久精品二区三区老狼| 玩弄放荡人妻一区二区三区| 亚洲精品国产综合久久一线| 国产午夜福利不卡在线秋霞秋霞| 久久人人玩人妻潮喷内射人人| 色与欲影视天天看综合网| 老汉色老汉首页a亚洲| 亚洲精品国产一区黑色丝袜| 色av综合av综合无码网站| 国产情侣真实54分钟在线| 国产av综合第一页| 亚洲国产精品成人久久| 国产精品久久久久久成人影院| 久久久久影院美女国产主播| 欧美老妇人与禽交| 精品无码久久久久久国产| 欧洲精品无码一区二区三区在线播放 | 精品一区二区三区无码视频| 亚洲精品制服丝袜四区|