在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ICAM2 Antibody

  • 中文名稱:
    ICAM2兔多克隆抗體
  • 貨號:
    CSB-PA010950ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA010950ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA010950ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ICAM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Intercellular adhesion molecule 2 protein (25-223AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
  • 基因功能參考文獻:
    1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. PMID: 29671117
    2. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway. PMID: 27556181
    3. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses PMID: 27592383
    4. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls. PMID: 26641849
    5. Soluble ICAM2 was higher in ADHD patients than in controls. PMID: 26377944
    6. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
    7. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus PMID: 24474251
    8. ICAM-2 was significantly more pronounced in plasma cell mastitis than in nonpathologic breast tissue. However, no significant differences in ICAM-2 immunoreactivity were detected between ductal epithelium of PCM and non-PCM. PMID: 24457076
    9. Reduced glycosylation of ICAM-2 significantly attenuated, but did not abolish, its ability to suppress metastatic properties of neuroblastoma cells. PMID: 23714211
    10. These findings suggested that the downregulated miR-125b expression was associated with proliferation and radioresistance mechanisms, probably through ICAM2 signalling. PMID: 23591197
    11. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
    12. Although ICAM-2 colocalizes with moesin and F-actin in microvilli of unstimulated endothelial cells, it is not involved in RhoA activation or cause stress fiber formation upon cross-linking. PMID: 12097408
    13. soluble DC-SIGN bound to gp120-Fc more than 100- and 50-fold better than ICAM-2-Fc and ICAM-3-Fc, respectively. Binding sites are described. PMID: 14970226
    14. The role of ICAM-2 has its recognition as potential therapeutic targets in human diseases. PMID: 15548573
    15. persistently elevated, serum levels of ICAM-2 throughout the various phases and types of Hemorrhagic fever with renal syndrome (HFRS) may be associated with the hyperfunctioning of the cellular immune response. PMID: 16987074
    16. pig and human ICAM-2 promoters exhibit many similarities PMID: 17059578
    17. The binding partner of DC-SIGN on endothelial cells is the glycan epitope Lewis(Y) (Le(Y)), expressed on ICAM-2. PMID: 18155766
    18. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. PMID: 18768213
    19. ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, microvillus.
  • 蛋白家族:
    Immunoglobulin superfamily, ICAM family
  • 數據庫鏈接:

    HGNC: 5345

    OMIM: 146630

    KEGG: hsa:3384

    STRING: 9606.ENSP00000388666

    UniGene: Hs.431460



主站蜘蛛池模板: 久久久精品人妻久久影视| 欧美变态另类牲交zozo| 少妇无套内谢久久久久| 久久亚洲精品ab无码播放| 久久精品国产最新地址| 国产mv在线天堂mv免费观看| 国产做爰又粗又大又爽动漫| 亚洲亚洲人成综合丝袜图片| 人妻无码中字在线a| 国产精品无码午夜福利| 中文国产成人精品久久不卡 | 日韩国产亚洲欧美中国v| 国产人妻久久精品二区三区| 亚洲乱码中文字幕综合234| 中文字幕人乱码中文| 亚洲综合图色40p| 欧美日韩国产精品自在自线| 日韩精品无码一区二区忘忧草| 亚洲综合无码一区二区三区不卡| 亚州中文字幕午夜福利电影| 天天爽夜夜爽人人爽曰| 无码人妻精品一区二区三区99不卡 | 亚洲精品国产suv一区| 久久国产36精品色熟妇| 午夜国人精品av免费看| 亚洲成a∧人片在线播放无码| 中国精学生妹品射精久久| 久久人人爽人人爽人人片av东京热| 亚洲国色天香卡2卡3卡4 | 久久久久人妻精品区一三寸| 日本乱码伦午夜福利在线| 北条麻妃在线一区二区| 西西人体www大胆高清| 国产精品99久久精品| 无码中字出轨中文人妻中文中| 青草国产精品久久久久久| 波多野结衣一区二区三区av高清| 日产一区日产2区| 久久www色情成人免费| 国产成人精品一区二区秒播| 亚洲国产成人无码av在线|