在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ICAM2 Antibody

  • 中文名稱:
    ICAM2兔多克隆抗體
  • 貨號:
    CSB-PA009375
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 3T3 cells using ICAM-2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD antigen CD102
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ICAM-2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
  • 基因功能參考文獻:
    1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. PMID: 29671117
    2. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway. PMID: 27556181
    3. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses PMID: 27592383
    4. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls. PMID: 26641849
    5. Soluble ICAM2 was higher in ADHD patients than in controls. PMID: 26377944
    6. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells. PMID: 24704826
    7. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus PMID: 24474251
    8. ICAM-2 was significantly more pronounced in plasma cell mastitis than in nonpathologic breast tissue. However, no significant differences in ICAM-2 immunoreactivity were detected between ductal epithelium of PCM and non-PCM. PMID: 24457076
    9. Reduced glycosylation of ICAM-2 significantly attenuated, but did not abolish, its ability to suppress metastatic properties of neuroblastoma cells. PMID: 23714211
    10. These findings suggested that the downregulated miR-125b expression was associated with proliferation and radioresistance mechanisms, probably through ICAM2 signalling. PMID: 23591197
    11. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
    12. Although ICAM-2 colocalizes with moesin and F-actin in microvilli of unstimulated endothelial cells, it is not involved in RhoA activation or cause stress fiber formation upon cross-linking. PMID: 12097408
    13. soluble DC-SIGN bound to gp120-Fc more than 100- and 50-fold better than ICAM-2-Fc and ICAM-3-Fc, respectively. Binding sites are described. PMID: 14970226
    14. The role of ICAM-2 has its recognition as potential therapeutic targets in human diseases. PMID: 15548573
    15. persistently elevated, serum levels of ICAM-2 throughout the various phases and types of Hemorrhagic fever with renal syndrome (HFRS) may be associated with the hyperfunctioning of the cellular immune response. PMID: 16987074
    16. pig and human ICAM-2 promoters exhibit many similarities PMID: 17059578
    17. The binding partner of DC-SIGN on endothelial cells is the glycan epitope Lewis(Y) (Le(Y)), expressed on ICAM-2. PMID: 18155766
    18. Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. PMID: 18768213
    19. ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein. Cell projection, microvillus.
  • 蛋白家族:
    Immunoglobulin superfamily, ICAM family
  • 數據庫鏈接:

    HGNC: 5345

    OMIM: 146630

    KEGG: hsa:3384

    STRING: 9606.ENSP00000388666

    UniGene: Hs.431460



主站蜘蛛池模板: 狠狠色丁香久久婷婷综合五月| 国产精品videossex久久发布 | 欧美乱妇高清无乱码免费| 国产欧美性成人精品午夜| 亚洲日本乱码中文在线电影| 婷婷开心激情综合五月天| 一二三四社区在线中文视频| 99久久国产成人免费网站| 日韩av无码国产精品| 国产精品免费大片| 国产欧美日韩视频怡春院| 无码人妻精品一区二区三区66| 在线天堂资源www| 中文字幕av一区乱码| 国内揄拍国内精品人妻| 少妇三级全黄| 国产女人高潮毛片| 国产亚洲人成网站在线观看| 国产亚洲精品久久久久久无| 久久精品人人槡人妻人| 亚洲妓女综合网99| 国产美女牲交视频| 无码潮喷a片无码高潮视频| 97无码精品综合| 丰满的人妻hd高清日本| 狠狠综合久久av一区二区| 国产精品免费福利久久| 伊人久久久大香线蕉综合直播| 亚洲一区在线日韩在线尤物| 亚洲αⅴ无码乱码在线观看性色| 欧美人与动人物牲交免费观看久久| 野花社区在线观看视频| 亚洲午夜无码久久久久软件| 日本少妇xxxx做受| 国产超碰人人做人人爽av动图| 精产国品一二三产区蘑菇视频| 北条麻妃一区二区三区av高清| 18禁成人网站免费观看| 无码成人一区二区| 人妻被按摩到潮喷中文不卡| 国产偷窥熟精品视频|