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  4. HMGN2 Antibody

HMGN2 Antibody

  • 中文名稱：
    HMGN2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009221
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    HMGN2
  • 別名：
    High mobility group (nonhistone chromosomal) protein 17 antibody; high mobility group nucleosomal binding domain 2 antibody; High mobility group nucleosome-binding domain-containing protein 2 antibody; High mobility group protein N2 antibody; HMG17 antibody; HMGN2 antibody; HMGN2_HUMAN antibody; MGC5629 antibody; Non histone chromosomal protein HMG 17 antibody; Non-histone chromosomal protein HMG-17 antibody; Nonhistone chromosomal protein HMG 17 antibody; nonhistone chromosomal protein hmg-17 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human HMG-17 around the non-phosphorylation site of S29.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
  • 基因功能參考文獻(xiàn)：
    1. these results uncover a novel link between nuclear protein HMGN2 and Nrf2-mediated cellular redox circumstance and suggest roles of HMGN2 in autonomous immune response to Pseudomonas aeruginosa infection PMID: 28408162
    2. HMGN1 and HMGN2 remodel core and linker histone tail domains within chromatin. PMID: 28973435
    3. Results provide evidence that HDAC6 could regulate HMGN2 acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells. PMID: 27358110
    4. elucidate a novel mechanism whereby the linker histone H1 prevents STAT5 binding at promoter DNA, and the PRL-induced dissociation of H1 mediated by HMGN2 is necessary to allow full STAT5 recruitment and promote the biological effects of PRL signaling PMID: 28035005
    5. Data show that high mobility group nucleosomal binding domain 2 (HMGN2) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization. PMID: 27460641
    6. Data show that chronic lymphocytic leukemia (CLL) cells present high-mobility group nucleosome-binding protein 2 (HMGN2) at membrane. PMID: 25156469
    7. enhanced expression of HMGN2 in osteosarcoma cells by HMGN2 lentivirus, exerts inhibitory effects on growth and migration of osteosarcoma cells. PMID: 25530340
    8. HMGN2 is an anti-tumor effector molecule of CD8 T cells. PMID: 25060707
    9. A polypeptide, HMGN2, was isolated and may be an antimicrobial effector molecule of mononuclear leukocytes. PMID: 16204630
    10. HMGN2 is modified by covalent attachment of small ubiquitin-related modifier 1 (SUMO1) by pro-inflammatory signal and identified the major SUMOylated lysine residues that localize to the HMGN2 nucleosome-binding domain at Lys-17 and Lys-35. PMID: 24872413
    11. HMGN2 is a bona fide Aurora B substrate in vivo and show that its dynamic association to chromatin is controlled by Aurora B. PMID: 22267324
    12. HMGN2 acts as a positive modulator of nuclear factor kappaB signalling to promote lipopolysaccharide-induced beta-defensin-2 expression. PMID: 21518253
    13. HMGN2 protein has antimicrobial activity and is probably involved in innate immunity in vivo. PMID: 20842856
    14. The association of the PRLr with HMGN2 enables Stat5a-responsive promoter binding, thus facilitating transcriptional activation and promoting anchorage-independent growth. PMID: 21816901
    15. HMGN2 binds to both the acidic patch in the histone H2A-H2B dimer and to nucleosomal DNA near the entry/exit point, "stapling" the histone core and the DNA. PMID: 21730181
    16. fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells and tumor endothelial cells in vivo PMID: 12032302
    17. each of the 4 amino acids in the R-S-RL motif are the only residues absolutely essential for anchoring HMGN protein to nucleosomes, both in vivo and in vitro. PMID: 18299391

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
  • 蛋白家族：
    HMGN family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4986

    OMIM: 163910

    KEGG: hsa:3151

    STRING: 9606.ENSP00000355228

    UniGene: Hs.181163



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