在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HMGN2 Antibody

  • 中文名稱:
    HMGN2兔多克隆抗體
  • 貨號:
    CSB-PA009219
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HMGN2
  • 別名:
    High mobility group (nonhistone chromosomal) protein 17 antibody; high mobility group nucleosomal binding domain 2 antibody; High mobility group nucleosome-binding domain-containing protein 2 antibody; High mobility group protein N2 antibody; HMG17 antibody; HMGN2 antibody; HMGN2_HUMAN antibody; MGC5629 antibody; Non histone chromosomal protein HMG 17 antibody; Non-histone chromosomal protein HMG-17 antibody; Nonhistone chromosomal protein HMG 17 antibody; nonhistone chromosomal protein hmg-17 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human HMG-17.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
  • 基因功能參考文獻:
    1. these results uncover a novel link between nuclear protein HMGN2 and Nrf2-mediated cellular redox circumstance and suggest roles of HMGN2 in autonomous immune response to Pseudomonas aeruginosa infection PMID: 28408162
    2. HMGN1 and HMGN2 remodel core and linker histone tail domains within chromatin. PMID: 28973435
    3. Results provide evidence that HDAC6 could regulate HMGN2 acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells. PMID: 27358110
    4. elucidate a novel mechanism whereby the linker histone H1 prevents STAT5 binding at promoter DNA, and the PRL-induced dissociation of H1 mediated by HMGN2 is necessary to allow full STAT5 recruitment and promote the biological effects of PRL signaling PMID: 28035005
    5. Data show that high mobility group nucleosomal binding domain 2 (HMGN2) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization. PMID: 27460641
    6. Data show that chronic lymphocytic leukemia (CLL) cells present high-mobility group nucleosome-binding protein 2 (HMGN2) at membrane. PMID: 25156469
    7. enhanced expression of HMGN2 in osteosarcoma cells by HMGN2 lentivirus, exerts inhibitory effects on growth and migration of osteosarcoma cells. PMID: 25530340
    8. HMGN2 is an anti-tumor effector molecule of CD8 T cells. PMID: 25060707
    9. A polypeptide, HMGN2, was isolated and may be an antimicrobial effector molecule of mononuclear leukocytes. PMID: 16204630
    10. HMGN2 is modified by covalent attachment of small ubiquitin-related modifier 1 (SUMO1) by pro-inflammatory signal and identified the major SUMOylated lysine residues that localize to the HMGN2 nucleosome-binding domain at Lys-17 and Lys-35. PMID: 24872413
    11. HMGN2 is a bona fide Aurora B substrate in vivo and show that its dynamic association to chromatin is controlled by Aurora B. PMID: 22267324
    12. HMGN2 acts as a positive modulator of nuclear factor kappaB signalling to promote lipopolysaccharide-induced beta-defensin-2 expression. PMID: 21518253
    13. HMGN2 protein has antimicrobial activity and is probably involved in innate immunity in vivo. PMID: 20842856
    14. The association of the PRLr with HMGN2 enables Stat5a-responsive promoter binding, thus facilitating transcriptional activation and promoting anchorage-independent growth. PMID: 21816901
    15. HMGN2 binds to both the acidic patch in the histone H2A-H2B dimer and to nucleosomal DNA near the entry/exit point, "stapling" the histone core and the DNA. PMID: 21730181
    16. fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells and tumor endothelial cells in vivo PMID: 12032302
    17. each of the 4 amino acids in the R-S-RL motif are the only residues absolutely essential for anchoring HMGN protein to nucleosomes, both in vivo and in vitro. PMID: 18299391

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
  • 蛋白家族:
    HMGN family
  • 數據庫鏈接:

    HGNC: 4986

    OMIM: 163910

    KEGG: hsa:3151

    STRING: 9606.ENSP00000355228

    UniGene: Hs.181163



主站蜘蛛池模板: 天堂资源中文最新版在线一区 | 国模雨珍浓密毛大尺度150p| 在线天堂资源www中文| 亚洲国产精品一区二区成人片国内| 欧美成人一区二免费视频软件| 精品久久久久成人码免费动漫| 性色a∨精品高清在线观看| 日夜啪啪一区二区三区| 国产精品视频观看裸模| 日韩欧美亚洲综合久久影院| 无码国产精品一区二区免费式影视| 女人被狂躁c到高潮视频| 国产mv在线天堂mv免费观看| 日韩人妻不卡一区二区三区| 女厕厕露p撒尿八个少妇| 亚洲成色www久久网站| av无码一区二区大桥久未| 亚洲一区二区制服在线| 无码免费中文字幕视频| 中文字幕av一区二区三区| 在厨房拨开内裤进入毛片| 亚洲天堂2017无码中文| 精品国产一区二区三区av片| 亚洲国产制服丝袜高清在线 | 日99久9在线 | 免费| 亚洲一区二区三区| 欧美xxxx精品另类| 99视频精品国产免费观看| 精品无码专区久久久水蜜桃| 97夜夜澡人人爽人人| 久久久久黑人强伦姧人妻| 人妻无码一区二区三区免费| 国产麻豆精品福利在线| 亚洲欧洲国产成人综合在线观看 | 免费的黄网站在线观看| 蜜臀亚洲精品国产aⅴ综合第一| 亚洲一区二区三区无码av| 一道本在线伊人蕉无码| 欧美性插b在线视频网站| 青草久久人人97超碰| 亚洲熟妇丰满xxxxx|