在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HMGN2 Antibody

  • 中文名稱:
    HMGN2兔多克隆抗體
  • 貨號:
    CSB-PA911918
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HMG17 antibody.
    • Immunofluorescence analysis of HeLa cells, using HMG17 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HMGN2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HMGN2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human HMG17.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
  • 基因功能參考文獻:
    1. these results uncover a novel link between nuclear protein HMGN2 and Nrf2-mediated cellular redox circumstance and suggest roles of HMGN2 in autonomous immune response to Pseudomonas aeruginosa infection PMID: 28408162
    2. HMGN1 and HMGN2 remodel core and linker histone tail domains within chromatin. PMID: 28973435
    3. Results provide evidence that HDAC6 could regulate HMGN2 acetylation levels and binding to Stat5a-responsive promoters, and therefore, Stat5a transcriptional activity in breast cancer cells. PMID: 27358110
    4. elucidate a novel mechanism whereby the linker histone H1 prevents STAT5 binding at promoter DNA, and the PRL-induced dissociation of H1 mediated by HMGN2 is necessary to allow full STAT5 recruitment and promote the biological effects of PRL signaling PMID: 28035005
    5. Data show that high mobility group nucleosomal binding domain 2 (HMGN2) knockdown induced the increased expression of alpha5beta1 integrin on cell membranes, which resulted in a significant increase in Klebsiella pneumoniae internalization. PMID: 27460641
    6. Data show that chronic lymphocytic leukemia (CLL) cells present high-mobility group nucleosome-binding protein 2 (HMGN2) at membrane. PMID: 25156469
    7. enhanced expression of HMGN2 in osteosarcoma cells by HMGN2 lentivirus, exerts inhibitory effects on growth and migration of osteosarcoma cells. PMID: 25530340
    8. HMGN2 is an anti-tumor effector molecule of CD8 T cells. PMID: 25060707
    9. A polypeptide, HMGN2, was isolated and may be an antimicrobial effector molecule of mononuclear leukocytes. PMID: 16204630
    10. HMGN2 is modified by covalent attachment of small ubiquitin-related modifier 1 (SUMO1) by pro-inflammatory signal and identified the major SUMOylated lysine residues that localize to the HMGN2 nucleosome-binding domain at Lys-17 and Lys-35. PMID: 24872413
    11. HMGN2 is a bona fide Aurora B substrate in vivo and show that its dynamic association to chromatin is controlled by Aurora B. PMID: 22267324
    12. HMGN2 acts as a positive modulator of nuclear factor kappaB signalling to promote lipopolysaccharide-induced beta-defensin-2 expression. PMID: 21518253
    13. HMGN2 protein has antimicrobial activity and is probably involved in innate immunity in vivo. PMID: 20842856
    14. The association of the PRLr with HMGN2 enables Stat5a-responsive promoter binding, thus facilitating transcriptional activation and promoting anchorage-independent growth. PMID: 21816901
    15. HMGN2 binds to both the acidic patch in the histone H2A-H2B dimer and to nucleosomal DNA near the entry/exit point, "stapling" the histone core and the DNA. PMID: 21730181
    16. fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells and tumor endothelial cells in vivo PMID: 12032302
    17. each of the 4 amino acids in the R-S-RL motif are the only residues absolutely essential for anchoring HMGN protein to nucleosomes, both in vivo and in vitro. PMID: 18299391

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
  • 蛋白家族:
    HMGN family
  • 數據庫鏈接:

    HGNC: 4986

    OMIM: 163910

    KEGG: hsa:3151

    STRING: 9606.ENSP00000355228

    UniGene: Hs.181163



主站蜘蛛池模板: 国产又大又黑又粗免费视频| 国产婷婷综合在线视频| 狠狠躁18三区二区一区ai明星| 亚洲色偷精品一区二区三区| 国产极品精品自在线| 女性自慰网站免费观看w| 偷妻之寂寞难耐2中文字幕 | 久久av无码精品人妻系列| 亚洲一卡一卡二新区无人区 | 亚洲欧洲∨国产一区二区三区| 国产高清视频色拍| 亚洲人毛茸茸bbxx| 潮喷大喷水系列无码| 免费看成人aa片无码视频吃奶| 成人精品视频一区二区三区 | 国产精品女人呻吟在线观看| 中文字幕在线影视| 99久久精品无码一区二区三区| 亚洲日韩在线中文字幕线路2区| 国产午夜亚洲精品一区| 亚洲最大av网站在线观看| 57pao成人国产永久免费视频| 亚洲综合小说另类图片五月天| 久久无码精品一一区二区三区| 国产96在线 | 亚洲| 性欧美丰满熟妇xxxx性久久久| 美女人妻激情乱人伦| 少妇激情艳情综合小视频| 久久久久久自慰出白浆| 久久精品免费国产大片| 久久精品av一区二区免费| 97久久精品人妻人人搡人人玩| 无码精品国产一区二区三区免费| 国产在线无码视频一区二区三区| 色诱视频在线观看| 女人被狂躁到高潮视频免费软件| 国产在线观看免费观看不卡| 我的性奴的肉玩具1一17心奴| 国产免费视频| 欧洲无码精品a码无人区| 亚洲熟妇无码av不卡在线播放|