在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HCCS Antibody

  • 中文名稱:
    HCCS兔多克隆抗體
  • 貨號:
    CSB-PA002862
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COS7 cells using HCCS Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HCCS
  • 別名:
    CCHL antibody; CCHL_HUMAN antibody; cytochrome c heme-lyase antibody; Cytochrome c-type heme lyase antibody; DKFZp779I1858 antibody; EC 4.4.1.17 antibody; Hccs antibody; Holocytochrome c synthase (cytochrome c heme lyase) antibody; Holocytochrome c synthase antibody; Holocytochrome c type synthase antibody; Holocytochrome c-type synthase antibody; MCOPS7 antibody; OTTHUMP00000022903 antibody; OTTHUMP00000022904 antibody; OTTHUMP00000022905 antibody; OTTMUSP00000021173 antibody; OTTMUSP00000021174 antibody; RGD1563855 antibody; RP23-37L2.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human HCCS.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
  • 基因功能參考文獻:
    1. Data suggest that although HCCS mediates heme attachment to N-terminal cysteine in heme-attachment site (CXXXH) of cytochrome C variants, up to 50% of cytochrome C produced is modified in an oxygen-dependent manner, resulting in a mixed population of cytochrome c. [HCCS = holocytochrome c synthase] PMID: 28617588
    2. Bacterial cyt c biogenesis pathways (Systems I and II) appear to recognize simply the CXXCH motif, not requiring alpha helix-1. Results here explain mechanistically how HCCS (System III) requires an extended region adjacent to CXXCH for maturation. PMID: 27387500
    3. cysteines and histidine of the heme attachment site, Cys-XX-Cys-His play a key role in mitochondrial holocytochrome c synthase PMID: 25170082
    4. These data indicate that heme contacts mediated by residues within these domains modulate the dynamics of heme binding and contribute to the stability of the HCCS-heme-cytochrome c steady state ternary complex. PMID: 25054239
    5. Identification of a deletion in two patients, including HCCS, leads to the diagnosis of microphthalmia with linear skin defects syndrome PMID: 23401659
    6. Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c revealed the fundamental steps of heme attachment and maturation. PMID: 23150584
    7. Through the study of genetically engineered mice, the loss of HCCS is demonstrated to cause the male lethality of microphthalmia with linear skin defects (MLS) syndrome. PMID: 12444108
    8. mutant proteins (R217C and Delta 197-268) were unable to complement a Saccharomyces cerevisiae mutant deficient for the HCCS orthologue Cyc3p, in contrast to wild-type HCCS PMID: 17033964
    9. Missense mutation p.E159K of HCCS, leading to loss-of-function of encoded holocytochrome c-type synthase, in female with microphthalmia of both eyes and bilateral sclerocornea may suggest HCCS as candidate for severe ocular manifestations. PMID: 17893649

    顯示更多

    收起更多

  • 相關疾病:
    Linear skin defects with multiple congenital anomalies 1 (LSDMCA1)
  • 亞細胞定位:
    Mitochondrion inner membrane. Membrane; Lipid-anchor.
  • 蛋白家族:
    Cytochrome c-type heme lyase family
  • 數據庫鏈接:

    HGNC: 4837

    OMIM: 300056

    KEGG: hsa:3052

    STRING: 9606.ENSP00000326579

    UniGene: Hs.211571



主站蜘蛛池模板: 情侣激情18内射骚话国产 | 国产成人无码一区二区三区在线| 日本大乳高潮视频在线观看| 97人洗澡人人澡人人爽人人模| 欧美婷婷六月丁香综合| 久久97超碰色中文字幕总站| 欧美俄罗斯乱妇| 久久日本三级韩国三级| 极品国产主播粉嫩在线| 强伦姧人妻免费无码电影| 久热在线播放中文字幕| 久久久久国产精品嫩草影院 | 婷婷成人综合激情在线视频播放| 久久无码国产专区精品| 东京热一精品无码av| 韩国三级l中文字幕无码| 中文字幕av一区二区三区| 初尝人妻少妇中文字幕| 狠狠精品久久久无码中文字幕| 欧美成人形色生活片| 亚洲最大成人网站| 日本特黄特色特爽大片| 国产福利日本一区二区三区| 亚州中文字幕午夜福利电影| 深夜福利视频在线播放| 亚洲精品亚洲人成在线观看| 国产高清精品软件丝瓜软件| 国产午夜精品av一区二区麻豆| 国产区女主播在线观看| 永久免费观看黄网视频| 一边啪啪一边呻吟av夜夜嗨 | 亚洲香蕉网久久综合影视| 亚洲精品乱码久久久久蜜桃| 日韩一欧美内射在线观看| 亚洲aⅴ综合色区无码一区| 日本熟妇美熟bbw| 亚洲精品乱码久久久久久自慰| 中文字幕在线日亚州9| 亚洲另类欧美综合在线| 国产超级va在线观看视频| 久久无码人妻一区二区三区|