在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRM6 Antibody

  • 中文名稱:
    GRM6兔多克隆抗體
  • 貨號:
    CSB-PA009033
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CSNB1B antibody; DKFZp686H1993 antibody; GluR6 antibody; Glutamate receptor metabotropic 6 antibody; GPRC1F antibody; Grm6 antibody; GRM6_HUMAN antibody; Metabotropic glutamate receptor 6 antibody; mGlu6 antibody; mGluR6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human mGluR-6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
  • 基因功能參考文獻:
    1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
    2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness. PMID: 26628857
    3. These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin. PMID: 23452348
    4. We found 5 different mutations in GRM6, in congenital stationary night blindness. PMID: 23714322
    5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina. PMID: 22959359
    6. The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB). PMID: 22735794
    7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction. PMID: 22008250
    8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
    9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6. PMID: 16249515
    10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface. PMID: 17405131
    11. A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype. PMID: 19666700
    12. Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases. PMID: 19862333

    顯示更多

    收起更多

  • 相關疾病:
    Night blindness, congenital stationary, 1B (CSNB1B)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 組織特異性:
    Detected in melanocytes.
  • 數據庫鏈接:

    HGNC: 4598

    OMIM: 257270

    KEGG: hsa:2916

    STRING: 9606.ENSP00000231188

    UniGene: Hs.248131



主站蜘蛛池模板: 天天躁夜夜躁狠狠眼泪| 国产日韩在线视看高清视频手机 | 精品国产福利拍拍拍| 亚洲大尺度无码专区尤物| 中文字幕一区二区人妻| 午夜福利片手机在线播放| 亚洲中文字幕不卡无码| 国内熟妇人妻色无码视频在线| 奶头好大狂揉60分钟视频| 十八18禁国产精品www| 精品国产乱码久久久久久夜深人妻| 欧美性生交活xxxxxdddd| 久久www免费人成看片入口| 国产精品久久久久无码av色戒| 美女扒开屁股让男人桶| 亚洲精品无码av黄瓜影视| 中文人妻av大区中文不卡| 国产乱辈通伦影片在线播放亚洲| 偷偷色噜狠狠狠狠的777米奇| 2020无码专区人妻系列日韩| 色窝窝色蝌蚪在线视频| 国产成在线观看免费视频| 丰满白嫩人妻中出无码| 久久久久久av无码免费看大片| 人妻教师痴汉电车波多野结衣 | 国产美女爽到尿喷出来视频| 少妇呻吟白浆高潮啪啪69| 又大又紧又粉嫩18p少妇| 亚洲精品一区| 夜夜爱夜夜做夜夜爽| 久久久久国产精品人妻aⅴ四季| 精品国产在天天在线观看| 色婷婷综合中文久久一本| 免费又黄又裸乳的视频| 伊人久久大香线蕉综合5g| 老子影院午夜伦手机不四虎卡| 内射囯产旡码丰满少妇| 韩国三级中文字幕hd久久精品| 国产精品尹人在线观看| 中日产幕无线码一区| 国产又黄又猛又粗又爽的a片动漫|