在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRM6 Antibody, HRP conjugated

  • 中文名稱:
    GRM6兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA009936LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GRM6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CSNB1B antibody; DKFZp686H1993 antibody; GluR6 antibody; Glutamate receptor metabotropic 6 antibody; GPRC1F antibody; Grm6 antibody; GRM6_HUMAN antibody; Metabotropic glutamate receptor 6 antibody; mGlu6 antibody; mGluR6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Metabotropic glutamate receptor 6 protein (370-531AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
  • 基因功能參考文獻:
    1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
    2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness. PMID: 26628857
    3. These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin. PMID: 23452348
    4. We found 5 different mutations in GRM6, in congenital stationary night blindness. PMID: 23714322
    5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina. PMID: 22959359
    6. The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB). PMID: 22735794
    7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction. PMID: 22008250
    8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
    9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6. PMID: 16249515
    10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface. PMID: 17405131
    11. A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype. PMID: 19666700
    12. Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases. PMID: 19862333

    顯示更多

    收起更多

  • 相關疾病:
    Night blindness, congenital stationary, 1B (CSNB1B)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 組織特異性:
    Detected in melanocytes.
  • 數據庫鏈接:

    HGNC: 4598

    OMIM: 257270

    KEGG: hsa:2916

    STRING: 9606.ENSP00000231188

    UniGene: Hs.248131



主站蜘蛛池模板: 伦伦影院午夜理论片| 亚洲精品无码久久毛片波多野吉衣| 国产av久久久久精东av| 亚洲乱码日产精品bd在观看| 免费无码精品黄av电影| 亚洲乱码中文字幕久久孕妇黑人| 国产mv在线天堂mv免费观看| 无码一区二区三区av免费蜜桃| 上海少妇高潮狂叫喷水了| 色狠狠成人综合网| 热re99久久精品国产66热| 国产毛片精品av一区二区| 亚洲一区在线日韩在线尤物| 日产精品久久久久久久蜜臀| 欧美疯狂性受xxxxx另类| 久久精品农村毛片| 成年黄页网站大全免费无码| 国产成人久久777777| 久久精品黄aa片一区二区三区 | 日本公与熄乱理在线播放| 国产在线不卡人成视频| 国产又色又爽又黄的视频在线 | 日韩久久无码免费毛片软件 | 亚洲精品亚洲人成在线观看| 人人妻碰人人免费| 人人妻人人澡人人爽精品日本| 麻豆人妻少妇精品无码专区| 337p人体 欧洲人体 亚洲| 99久e在线精品视频在线| 欧美精品在线观看| 欧美老妇与zozozo交| 中文字幕卡二和卡三的视频| 国产亚洲中文字幕在线制服| 国产内射老熟女aaaa| 亚洲国产精品特色大片观看完整版| 国产欧美日韩另类在线专区| 国产免费极品av吧在线观看| 中国孕妇变态孕交xxxx| 中文字幕日本特黄aa毛片| 护士av无码在线观看| 国产精品免费看久久久|