在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GRM6 Antibody, Biotin conjugated

GRM6 Antibody, Biotin conjugated

  • 中文名稱：
    GRM6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA009936LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GRM6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CSNB1B antibody; DKFZp686H1993 antibody; GluR6 antibody; Glutamate receptor metabotropic 6 antibody; GPRC1F antibody; Grm6 antibody; GRM6_HUMAN antibody; Metabotropic glutamate receptor 6 antibody; mGlu6 antibody; mGluR6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Metabotropic glutamate receptor 6 protein (370-531AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
  • 基因功能參考文獻：
    1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
    2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness. PMID: 26628857
    3. These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin. PMID: 23452348
    4. We found 5 different mutations in GRM6, in congenital stationary night blindness. PMID: 23714322
    5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina. PMID: 22959359
    6. The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB). PMID: 22735794
    7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction. PMID: 22008250
    8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
    9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6. PMID: 16249515
    10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface. PMID: 17405131
    11. A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype. PMID: 19666700
    12. Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases. PMID: 19862333

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Night blindness, congenital stationary, 1B (CSNB1B)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Detected in melanocytes.
  • 數據庫鏈接：

    HGNC: 4598

    OMIM: 257270

    KEGG: hsa:2916

    STRING: 9606.ENSP00000231188

    UniGene: Hs.248131



主站蜘蛛池模板： 97久久久久人妻精品区一| 久久综合久久久久88| 亚洲色婷婷久久精品av蜜桃| 亚洲视频日本有码中文| 人妻无码vs中文字幕久久av爆 | 2018亚洲а∨天堂| 精品露脸国产偷人在视频 | 国产啪视频1000部免费| 久久精品国产成人av| 另类老妇奶性生bbwbbw| 国产aⅴ精品一区二区三区久久 | 12裸体自慰免费观看网站| 中文字幕av无码一二三区电影| 亚洲国产欧美在线观看| 中文在线а√天堂官网| 蜜桃av亚洲精品一区二区| 中文字幕 亚洲精品 第1页| 黄页网址大全免费观看| 8av国产精品爽爽ⅴa在线观看| 亚洲2020天天堂在线观看| 十八禁av无码免费网站| 亚洲日韩中文字幕一区| 女人张开双腿让男人猛桶| 在教室伦流澡到高潮h麻豆| 国产精品一区二区无线| 性人久久网av| 综合久久久久6亚洲综合| 极品人妻少妇一区二区三区| 97精品人妻系列无码人妻| 久久久精品欧美一区二区免费| 波多野结av在线无码中文| 国产精品人人做人人爽| 夜夜爽一区二区三区精品| 久久久精品妇女99| 国产精品无码dvd在线观看| 人妻熟妇乱又伦精品视频中文字幕| 国产熟女出轨做受的叫床声| 激情国产av做激情国产爱| 久久综合伊人77777麻豆| 99久久国语露脸精品国产色| 免费乱理伦片在线观看八戒|