在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRM6 Antibody, Biotin conjugated

  • 中文名稱:
    GRM6兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA009936LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GRM6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CSNB1B antibody; DKFZp686H1993 antibody; GluR6 antibody; Glutamate receptor metabotropic 6 antibody; GPRC1F antibody; Grm6 antibody; GRM6_HUMAN antibody; Metabotropic glutamate receptor 6 antibody; mGlu6 antibody; mGluR6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Metabotropic glutamate receptor 6 protein (370-531AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
  • 基因功能參考文獻:
    1. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
    2. Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness. PMID: 26628857
    3. These data suggest differences in coupling of TRPM1 function to mGluR6 signaling explain different cellular responses to glutamate in the retina and the skin. PMID: 23452348
    4. We found 5 different mutations in GRM6, in congenital stationary night blindness. PMID: 23714322
    5. The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina. PMID: 22959359
    6. The results expand the mutation spectrum of NYX, CACNA1F and GRM6. They also suggest that NYX mutations are a common cause of congenital stationary night blindness (CSNB). PMID: 22735794
    7. The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction. PMID: 22008250
    8. A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6. PMID: 20560679
    9. Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6. PMID: 16249515
    10. The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface. PMID: 17405131
    11. A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate receptor mGlur6 phenotype. PMID: 19666700
    12. Three novel variations with potential functional consequences were identified in the GRM6 of patients with high myopia, suggesting a potential role in the development of myopia in rare cases. PMID: 19862333

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Night blindness, congenital stationary, 1B (CSNB1B)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
  • 蛋白家族:
    G-protein coupled receptor 3 family
  • 組織特異性:
    Detected in melanocytes.
  • 數據庫鏈接:

    HGNC: 4598

    OMIM: 257270

    KEGG: hsa:2916

    STRING: 9606.ENSP00000231188

    UniGene: Hs.248131



主站蜘蛛池模板: 高潮射精日本韩国在线播放 | 欧美变态另类xxxx| 久久不见久久见www免费| 国产精品丝袜亚洲熟女| 高中国产开嫩苞实拍视频在线观看 | 国产av亚洲精品久久久久久小说| 亲近乱子伦免费视频| 成人性生交大片免费卡看| 欧美变态另类刺激| 激情欧美日韩一区二区| 国产在线精品无码不卡手机免费| 日韩精品国产另类专区| 在线天堂免费观看.www| 又大又硬又黄的免费视频| 在线观看特色大片免费网站| 精品无码国产自产拍在线观看蜜 | 狠狠色噜噜狠狠狠狠五月婷| 玩弄白嫩少妇xxxxx性| 动漫精品啪啪一区二区三区| 国产69久久精品成人看| 日本亚洲vr欧美不卡高清专区| 日本大片免费观看视频| 亚洲成av人最新无码| www一区二区www免费| 小sao货水好多真紧h无码视频 | 亚洲日韩va无码中文字幕| 亚洲人成网站在线播放小说| 日本亚洲欧美日韩国产ay| 欧美z0zo人禽交免费观看99| 午夜不卡av免费| 和岳每晚弄的高潮嗷嗷叫视频| 国产乱人伦偷精品视频免观看 | 少妇熟女高潮流白浆| 亚洲国色天香卡2卡3卡4| 色噜噜狠狠色综合网| 国产午夜福利伦理300| 国产精品久久一区二区三区| 亚洲精品久久久蜜桃| 亚洲精品成人网线在线播放va| 伦埋琪琪久久影院三级| 精品日本一区二区三区在线观看|