在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GP Antibody, HRP conjugated

GP Antibody, HRP conjugated

Rare Species
  • 中文名稱：
    GP兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA350772LB01ZAT
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Zaire ebolavirus GP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GP
  • 別名：
    GP antibody; Pre-small/secreted glycoprotein antibody; pre-sGP) [Cleaved into: Small/secreted glycoprotein antibody; sGP); Delta-peptide] antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Zaire ebolavirus
  • 免疫原：
    Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein protein (33-364AA)
  • 免疫原種屬：
    Zaire ebolavirus
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils.; Viroporin that permeabilizes mammalian cell plasma membranes. It acts by altering permeation of ionic compounds and small molecules. This activity may lead to viral enterotoxic activity.
  • 基因功能參考文獻(xiàn)：
    1. Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway. PMID: 30021890
    2. the structure of the membrane proximal external region (MPER) connected to the TM domain: i.e., the missing parts of the EBOV GP2 structure. The structure, solved by solution NMR and EPR spectroscopy in membrane-mimetic environments, consists of a helix-turn-helix architecture that is independent of pH. PMID: 28874543
    3. Ebola virus GP directly subverts the host's immune response by increasing the susceptibility of monocytes to Ebola virus infection. PMID: 28542576
    4. report provides experimental evidence that the spontaneous mutation T544I is a tissue culture adaptation in certain cell lines and that it may be unique for the species Zaire ebolavirus; the mutation led to a marked increase in virus growth kinetics and conferred a robust growth advantage over wild-type rVSV-MAK-GP on Vero E6 cells PMID: 28539437
    5. although Asn(563) and Asn(618) are not required for EBOV GP expression, they synergistically regulate its maturation, which determines its functionality. PMID: 28196864
    6. Study determined the crystal structure of the primed GP (GPcl) of Ebola virus bound to domain C of NPC1 (NPC1-C); NPC1-C utilizes two protruding loops to engage a hydrophobic cavity on head of GPcl. Upon enzymatic cleavage and NPC1-C binding, conformational change in the GPcl further affects the state of the internal fusion loop, triggering membrane fusion. PMID: 26771495
    7. GP1,2 expression levels have a profound effect on factors that contribute to virus fitness and RNA editing may be an important mechanism employed by EBOV to regulate GP1,2 expression in order to optimize virus production and infectivity. PMID: 25392212
    8. Mucin-like domain is located at the apex and the sides of each glycoprotein monomer. PMID: 25008940
    9. The glycoprotein's internal fusion loop is critical for viral entry and fusion. PMID: 24696482
    10. GP play multiple functions including virus attachment and entry, cell rounding and cytotoxicity and down-regulation of host surface proteins.[review] PMID: 23757858
    11. findings demonstrate that a GP mutant, GP-F88A, defective for entry into a variety of human cell types, including antigen-presenting cells (APCs) can mediate viral entry into mouse CD11b( ) APCs; studies suggest an important role for NPC1 in the differential entry of GP-F88A into mouse versus human APCs PMID: 23302883
    12. Purified human NPC1 binds only to a cleaved form of Ebola virus spike glycoprotein that is generated within cells during entry, and only viruses containing cleaved glycoprotein can utilize a receptor retargeted to the cell surface. PMID: 22395071
    13. Ebola virus GP forms a tandem beta-hairpin structure that binds deeply into a cleft in the antibody-combining site. PMID: 22171276
    14. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression. PMID: 22222211
    15. Cathepsin L cleavage potentiates the Ebola virus GP to undergo a fusion-relevant conformational change. PMID: 22031933
    16. R64 and K95 of GP1 are involved in receptor binding. PMID: 21667336
    17. liposome fusion data and NMR structures for a complete (54-residue) disulfide-bonded internal fusion loop (Ebov FL) in a membrane mimetic PMID: 21690393
    18. Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. PMID: 21529875
    19. While ssGP appears to share similar structural properties with sGP, it does not appear to have the same anti-inflammatory function on endothelial cells as sGP. PMID: 21411529
    20. These findings suggest that Ebola virus GP uses a novel mechanism to circumvent tetherin restriction. PMID: 20444895
    21. CatB cleavage is required to facilitate the triggering of viral membrane fusion by destabilizing the prefusion conformation of EBOV GP PMID: 19846533
    22. Ebola virus GP cytotoxicity is regulated by dynamin-dependent cellular protein trafficking PMID: 15596847
    23. The transmembrane region of GP2 modifies the permeability of the plasma membrane. PMID: 16927113
    24. the crystal structure of EBOV GP in its trimeric, pre-fusion conformation (GP1+GP2) bound to a neutralizing antibody, KZ52, derived from a human survivor of the 1995 Kikwit outbreak PMID: 18615077
    25. The authors show that the mucin domain from the highly pathogenic Zaire subtype of Ebola virus is sufficient to cause characteristic cytopathology when expressed in the context of a foreign glycoprotein. PMID: 19013626

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Small/secreted glycoprotein]: Secreted.; [Delta-peptide]: Secreted.
  • 蛋白家族：
    Filoviruses glycoprotein family


主站蜘蛛池模板： 天天碰免费上传视频| 亚洲乱码国产乱码精品精| 国产精品自在线拍国产电影| 亚洲乱码无码永久不卡在线| 亚洲视频无码高清在线| 中日产幕无线码一区| 色翁荡熄又大又硬又粗又动态图| 1000部拍拍拍18勿入免费视频下载| 男人下部进女人下部视频| 亚洲乱码无人区卡1卡2卡3| 国内少妇偷人精品视频| 国产精品视频免费一区二区| 国精产品一品二品国精在线观看| 国产成人精品一区二区三区视频| 国产乡下三级全黄三级bd| 国产亚洲综合欧美视频| 国产av一区二区精品久久凹凸| 88国产精品视频一区二区三区| 国产成人av综合久久| 国产成人免费永久播放视频平台 | 中文午夜人妻无码看片| 自拍偷自拍亚洲精品播放| 亚洲精品国产一区二区| 青青青国产精品国产精品美女| 亚洲国产老鸭窝一区二区三区| 日本一卡2卡3卡四卡精品网站| 男女高潮又爽又黄又无遮挡| 国产99视频精品专区| 久久人人97超碰caoporen| 97伦伦午夜电影理伦片| 中文字幕亚洲乱码熟女一区二区| 日产精品1区2区3区| 国产精品久久久久一区二区三区| 久久人人爽人人爽人人片av高请| 黄页网站在线观看免费视频| 日本丰满少妇bbb| 在线观看老湿视频福利| 中文幕无线码中文字蜜桃| 亚洲aⅴ在线无码播放毛片一线天| 热re99久久精品国产99热| 中文字幕无码一区二区免费|