在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GP Antibody, Biotin conjugated

Rare Species
  • 中文名稱:
    GP兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA350772LD01ZAT
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Zaire ebolavirus GP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GP
  • 別名:
    GP antibody; Pre-small/secreted glycoprotein antibody; pre-sGP) [Cleaved into: Small/secreted glycoprotein antibody; sGP); Delta-peptide] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Zaire ebolavirus
  • 免疫原:
    Recombinant Zaire ebolavirus Pre-small/secreted glycoprotein protein (33-364AA)
  • 免疫原種屬:
    Zaire ebolavirus
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils.; Viroporin that permeabilizes mammalian cell plasma membranes. It acts by altering permeation of ionic compounds and small molecules. This activity may lead to viral enterotoxic activity.
  • 基因功能參考文獻:
    1. Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway. PMID: 30021890
    2. the structure of the membrane proximal external region (MPER) connected to the TM domain: i.e., the missing parts of the EBOV GP2 structure. The structure, solved by solution NMR and EPR spectroscopy in membrane-mimetic environments, consists of a helix-turn-helix architecture that is independent of pH. PMID: 28874543
    3. Ebola virus GP directly subverts the host's immune response by increasing the susceptibility of monocytes to Ebola virus infection. PMID: 28542576
    4. report provides experimental evidence that the spontaneous mutation T544I is a tissue culture adaptation in certain cell lines and that it may be unique for the species Zaire ebolavirus; the mutation led to a marked increase in virus growth kinetics and conferred a robust growth advantage over wild-type rVSV-MAK-GP on Vero E6 cells PMID: 28539437
    5. although Asn(563) and Asn(618) are not required for EBOV GP expression, they synergistically regulate its maturation, which determines its functionality. PMID: 28196864
    6. Study determined the crystal structure of the primed GP (GPcl) of Ebola virus bound to domain C of NPC1 (NPC1-C); NPC1-C utilizes two protruding loops to engage a hydrophobic cavity on head of GPcl. Upon enzymatic cleavage and NPC1-C binding, conformational change in the GPcl further affects the state of the internal fusion loop, triggering membrane fusion. PMID: 26771495
    7. GP1,2 expression levels have a profound effect on factors that contribute to virus fitness and RNA editing may be an important mechanism employed by EBOV to regulate GP1,2 expression in order to optimize virus production and infectivity. PMID: 25392212
    8. Mucin-like domain is located at the apex and the sides of each glycoprotein monomer. PMID: 25008940
    9. The glycoprotein's internal fusion loop is critical for viral entry and fusion. PMID: 24696482
    10. GP play multiple functions including virus attachment and entry, cell rounding and cytotoxicity and down-regulation of host surface proteins.[review] PMID: 23757858
    11. findings demonstrate that a GP mutant, GP-F88A, defective for entry into a variety of human cell types, including antigen-presenting cells (APCs) can mediate viral entry into mouse CD11b( ) APCs; studies suggest an important role for NPC1 in the differential entry of GP-F88A into mouse versus human APCs PMID: 23302883
    12. Purified human NPC1 binds only to a cleaved form of Ebola virus spike glycoprotein that is generated within cells during entry, and only viruses containing cleaved glycoprotein can utilize a receptor retargeted to the cell surface. PMID: 22395071
    13. Ebola virus GP forms a tandem beta-hairpin structure that binds deeply into a cleft in the antibody-combining site. PMID: 22171276
    14. Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression. PMID: 22222211
    15. Cathepsin L cleavage potentiates the Ebola virus GP to undergo a fusion-relevant conformational change. PMID: 22031933
    16. R64 and K95 of GP1 are involved in receptor binding. PMID: 21667336
    17. liposome fusion data and NMR structures for a complete (54-residue) disulfide-bonded internal fusion loop (Ebov FL) in a membrane mimetic PMID: 21690393
    18. Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. PMID: 21529875
    19. While ssGP appears to share similar structural properties with sGP, it does not appear to have the same anti-inflammatory function on endothelial cells as sGP. PMID: 21411529
    20. These findings suggest that Ebola virus GP uses a novel mechanism to circumvent tetherin restriction. PMID: 20444895
    21. CatB cleavage is required to facilitate the triggering of viral membrane fusion by destabilizing the prefusion conformation of EBOV GP PMID: 19846533
    22. Ebola virus GP cytotoxicity is regulated by dynamin-dependent cellular protein trafficking PMID: 15596847
    23. The transmembrane region of GP2 modifies the permeability of the plasma membrane. PMID: 16927113
    24. the crystal structure of EBOV GP in its trimeric, pre-fusion conformation (GP1+GP2) bound to a neutralizing antibody, KZ52, derived from a human survivor of the 1995 Kikwit outbreak PMID: 18615077
    25. The authors show that the mucin domain from the highly pathogenic Zaire subtype of Ebola virus is sufficient to cause characteristic cytopathology when expressed in the context of a foreign glycoprotein. PMID: 19013626

    顯示更多

    收起更多

  • 亞細胞定位:
    [Small/secreted glycoprotein]: Secreted.; [Delta-peptide]: Secreted.
  • 蛋白家族:
    Filoviruses glycoprotein family


主站蜘蛛池模板: 熟妇人妻一区二区三区四区| 久久精品高清一区二区三区| 伊人精品成人久久综合97 | 免费看国产成年无码av| 丰满少妇大力进入| 女被男啪到哭的视频网站| 亚洲爆乳无码专区www| 综合久久—本道中文字幕| 色yeye香蕉凹凸视频在线观看| 中文字幕乱码亚洲无线三区| 久久久久国产一区二区| 青草青在线视频在线观看| 久久97超碰色中文字幕蜜芽| 欧美亚洲综合在线一区| 国产亚洲日韩在线三区| 国产人成高清在线视频99最全资源| 亚洲成av人片天堂网站| 国产92成人精品视频免费| 国产欧美二区综合| 加勒比中文字幕无码一区| 最近中文av字幕在线中文| 伊人激情av一区二区三区| 国产99视频精品专区| 亚洲国内成人精品网| 国产亚洲精品精华液| 精品丝袜人妻久久久久久| av无码国产精品色午夜| 2019日韩中文字幕mv| 阳茎伸入女人阳道视频免费| 国产欧美在线一区二区三| 亚洲国产成人无码精品| 国产激情久久久久久熟女老人| 一本色道无码道在线观看| 国产精品自在线拍亚洲另类| 精品人妻少妇一区二区三区| 欲香欲色天天天综合和网| 欧美亚洲色aⅴ大片| 亚洲国产一区二区a毛片| 亚洲日韩精品a∨片无码加勒比| 欧洲亚洲国产成人综合色婷婷 | 爆乳高潮喷水无码正在播放|