在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNMT Antibody

  • 中文名稱:
    GNMT兔多克隆抗體
  • 貨號:
    CSB-PA009628GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    GNMT
  • 別名:
    EC 2.1.1.20 antibody; Epididymis secretory sperm binding protein Li 182mP antibody; Glycine N methyltransferase antibody; Glycine N-methyltransferase antibody; Gnmt antibody; GNMT_HUMAN antibody; HEL S 182mP antibody; OTTHUMP00000016412 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human GNMT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
  • 基因功能參考文獻:
    1. Elevated GNMT protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
    2. In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk. PMID: 24800880
    3. GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon. PMID: 23883094
    4. The studies identify GNMT as a direct transcriptional target of the AR. PMID: 23997240
    5. DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC), and loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters PMID: 23475283
    6. single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer PMID: 22850906
    7. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
    8. GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior. PMID: 22264868
    9. GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis. PMID: 22415010
    10. In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway PMID: 22160218
    11. GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer PMID: 21572396
    12. This study suggests that the glycine N-methyltransferase STRP1 phenotype could modulate urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels in coke-oven workers exposed to PAHs. PMID: 21691217
    13. investigation of role of GNMT in methyl group homeostasis in liver: GNMT affects transmethylation kinetics, SAM synthesis, and conservation of methyl groups by limiting homocysteine remethylation flux; possible role of GNMT inactivation in hepatoma PMID: 21411609
    14. compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease PMID: 11810299
    15. Results suggest that GNMT alteration may be an early event in hepatocellular carcinoma development and that GNMT could be a new tumor susceptibility gene for hepatocellular carcinoma. PMID: 12566309
    16. GNMT 1289 C-->T polymorphism influences plasma homocysteine and is responsive to folate intake. PMID: 16317120
    17. GNMT is destabilized by a mutation. PMID: 17660255
    18. Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. PMID: 18624901
    19. GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models PMID: 19035462
    20. A transgenic mouse model is used together with in vitro methods to study the ability of the GNMT transgene to block the cytotoxic or carcinogenic activity of aflatoxin B1, a known causal agent of human hepatocellular carcinoma. PMID: 19146867
    21. Study identified a GNMT transcriptional start site at the 14th position upstream of the ATG codon; results indicate binding of the nuclear factor-Y (NF-Y) transcription factor to the CCAAT box (-71/-67) of the GNMT gene. PMID: 19439180

    顯示更多

    收起更多

  • 相關疾病:
    Glycine N-methyltransferase deficiency (GNMT deficiency)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
  • 組織特異性:
    Abundant in liver.
  • 數據庫鏈接:

    HGNC: 4415

    OMIM: 606628

    KEGG: hsa:27232

    STRING: 9606.ENSP00000361894

    UniGene: Hs.144914



主站蜘蛛池模板: 久久精品青草社区| 性色av免费观看| 一性一交一口添一摸视频| 免费无码毛片一区二区app| 蜜臀av一区二区| 欧美video性欧美熟妇| 国内熟妇人妻色无码视频在线| 久久精品无码专区免费| 在线a视频网站| 色欲综合久久躁天天躁蜜桃| 欧美人妻久久精品| 激情综合色五月丁香六月欧美| 国产人成视频在线视频| 97在线成人国产在线视频| 制服丝袜亚洲欧美中文字幕| 免费无码又爽又刺激高潮的视频| 亚洲中文字幕无码一久久区| 成在人线av无码免费高潮喷水| 伊人久久精品亚洲午夜| 国产精品久久久久久久久ktv| 国产人妻黑人一区二区三区| 人人妻人人澡人人爽人人精品97 | 久久99亚洲含羞草影院| 波多野av一区二区无码| 亚洲a∨国产av综合av下载| 国产极品美女高潮抽搐免费网站| 国产女人高潮抽搐叫床视频| 亚洲国产综合在线区尤物| 精品国产欧美一区二区| 成人亚洲欧美在线观看| 亚洲国产精品成人综合色| 亚洲精品久久久久avwww潮水| 色婷婷av久久久久久久| 一区二区三区四区在线 | 中国| 99久热国产精品视频尤物| 国产伦精品免编号公布| √8天堂资源地址中文在线| 亚洲国产精品无码久久久蜜芽| 女人喷潮完整视频| 亚洲日韩一页精品发布| 精品国产一区二区av麻豆不卡|