在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNMT Antibody

  • 中文名稱:
    GNMT兔多克隆抗體
  • 貨號:
    CSB-PA009628LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA009628LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA009628LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GNMT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GNMT
  • 別名:
    EC 2.1.1.20 antibody; Epididymis secretory sperm binding protein Li 182mP antibody; Glycine N methyltransferase antibody; Glycine N-methyltransferase antibody; Gnmt antibody; GNMT_HUMAN antibody; HEL S 182mP antibody; OTTHUMP00000016412 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Glycine N-methyltransferase protein (2-295AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,GNMT Antibody (CSB-PA009628LA01HU),的標記方式是Non-conjugated。對于GNMT Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA009628LB01HU GNMT Antibody, HRP conjugated ELISA
    FITC CSB-PA009628LC01HU GNMT Antibody, FITC conjugated
    Biotin CSB-PA009628LD01HU GNMT Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
  • 基因功能參考文獻:
    1. Elevated GNMT protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
    2. In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk. PMID: 24800880
    3. GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon. PMID: 23883094
    4. The studies identify GNMT as a direct transcriptional target of the AR. PMID: 23997240
    5. DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC), and loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters PMID: 23475283
    6. single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer PMID: 22850906
    7. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
    8. GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior. PMID: 22264868
    9. GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis. PMID: 22415010
    10. In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway PMID: 22160218
    11. GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer PMID: 21572396
    12. This study suggests that the glycine N-methyltransferase STRP1 phenotype could modulate urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels in coke-oven workers exposed to PAHs. PMID: 21691217
    13. investigation of role of GNMT in methyl group homeostasis in liver: GNMT affects transmethylation kinetics, SAM synthesis, and conservation of methyl groups by limiting homocysteine remethylation flux; possible role of GNMT inactivation in hepatoma PMID: 21411609
    14. compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease PMID: 11810299
    15. Results suggest that GNMT alteration may be an early event in hepatocellular carcinoma development and that GNMT could be a new tumor susceptibility gene for hepatocellular carcinoma. PMID: 12566309
    16. GNMT 1289 C-->T polymorphism influences plasma homocysteine and is responsive to folate intake. PMID: 16317120
    17. GNMT is destabilized by a mutation. PMID: 17660255
    18. Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. PMID: 18624901
    19. GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models PMID: 19035462
    20. A transgenic mouse model is used together with in vitro methods to study the ability of the GNMT transgene to block the cytotoxic or carcinogenic activity of aflatoxin B1, a known causal agent of human hepatocellular carcinoma. PMID: 19146867
    21. Study identified a GNMT transcriptional start site at the 14th position upstream of the ATG codon; results indicate binding of the nuclear factor-Y (NF-Y) transcription factor to the CCAAT box (-71/-67) of the GNMT gene. PMID: 19439180

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Glycine N-methyltransferase deficiency (GNMT deficiency)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
  • 組織特異性:
    Abundant in liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4415

    OMIM: 606628

    KEGG: hsa:27232

    STRING: 9606.ENSP00000361894

    UniGene: Hs.144914



主站蜘蛛池模板: 国产成人无码免费视频在线| 激情综合色五月丁香六月欧美| 无码丰满熟妇| 后入内射国产一区二区| 国精产品一二三区传媒公司| 狠狠躁日日躁夜夜躁2022麻豆| 精品一区二区国产在线观看| 岛国av无码免费无禁网站麦芽| 蜜臀久久99精品久久久久久小说 | 久久人人97超碰国产公开| 精品人妻少妇一区二区三区| 特黄大片又粗又大又暴| 日本三级手机在线播放线观看| 亚洲女人色综合小说| 国产精品99爱免费视频| 亚洲成a人片在线观看无码| 丁香色婷婷国产精品视频| 日本又色又爽又黄的a片吻戏| 国产精品jk白丝在线播放| 人妻丰满熟妇av无码区动漫| 国产亚洲精品久久yy50| av色综合久久天堂av色综合在 | 护士奶头又白又大又好摸视频| 久久精品国产99久久久古代| www亚洲精品久久久乳| 日本亚洲欧美日韩国产ay| 久久久久久久久久久综合日本 | 亚洲人成人网站在线观看| 精品国产一区二区三区四区阿崩| 中文字幕乱码一区av久久| 日本成熟少妇喷浆视频| 日本丰满熟妇hd| 国产高清在线a视频大全| 一二三四视频社区在线播放中国| 亚洲a片成人无码久久精品色欲| 国产三级做爰在线播放| 国产欧美精品aaaaaa片| 777奇米四色成人影视色区| 少妇被黑人4p到惨叫欧美人| 国产精品久久久久久人妻精品动漫| 国产欧美精品aaaaaa片|